Examinando por Autor "Castro-Sepulveda, Mauricio"

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    Ítem
    Impact of different exercise modalities on mitophagy in human skeletal muscle
    (Elsevier, 2025) Muñoz-Medina, Cristóbal; Carriel-Nesvara, Alfonso; Botella, Javier; Castro-Sepulveda, Mauricio
    Exercise induces profound mitochondrial adaptations in skeletal muscle, with different modalities uniquely influencing different branches of mitochondrial quality control (MQC). This review examines how endurance, resistance, and high-intensity interval training (HIIT) regulate mitophagy, the selective degradation of damaged mitochondria, in skeletal muscle (SkM). Research in rodents has shown that endurance exercise upregulates mitophagy primarily through the AMPK/PGC-1α signaling axis, promoting mitochondrial turnover and ensuring metabolic efficiency. In humans, high-intensity exercise increases mitophagy to a larger extent when compared to traditional endurance exercises. On the other hand, resistance exercise triggers alternative MQC mechanisms, including potential mitochondrial ejection. Collectively, these results suggest that mitophagy and MQC pathways are regulated in human SkM following exercise, but the specific molecular pathways seem to be specific to each exercise mode. Future studies should aim at disentangling the multiple mitophagy and MQC pathways in human SkM following exercise.
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    Ítem
    Uncovering the muscle clock–mitochondria axis through exercise
    (CellPress, 2025-12) Castro-Sepulveda, Mauricio
    Emerging evidence suggests an interplay between the molecular clock and mitochondrial dynamics in skeletal muscle. In this Forum article, we hypothesize that exercise, as a metabolic challenge, provides a powerful physiological model to investigate the clock–mitochondria axis and its regulatory role in muscle function and metabolic health in humans.