Mitochondria-SR interaction and mitochondrial fusion/fission in the regulation of skeletal muscle metabolism

Fecha
2023-07-01
Nota de Acceso
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Profe guĂ­a
TĂ­tulo de la revista
ISSN de la revista
TĂ­tulo del volumen
Editor
Elsevier
ISBN
ISSN
0026-0495
ISSNe
1532-8600
Resumen
Mitochondria-endoplasmic/sarcoplasmic reticulum (ER/SR) interaction and mitochondrial fusion/fission are critical processes that influence substrate oxidation. This narrative review summarizes the evidence on the effects of substrate availability on mitochondrial-SR interaction and mitochondria fusion/fission dynamics to modulate substrate oxidation in human skeletal muscle. Evidence shows that an increase in mitochondria-SR interaction and mitochondrial fusion are associated with elevated fatty acid oxidation. In contrast, a decrease in mitochondria-SR interaction and an increase in mitochondrial fission are associated with an elevated glycolytic activity. Based on the evidence reviewed, we postulate two hypotheses for the link between mitochondrial dynamics and insulin resistance in human skeletal muscle. First, glucose and fatty acid availability modifies mitochondria-SR interaction and mitochondrial fusion/fission to help the cell to adapt substrate oxidation appropriately. Individuals with an impaired response to these substrate challenges will accumulate lipid species and develop insulin resistance in skeletal muscle. Second, a chronically elevated substrate availability (e.g. overfeeding) increases mitochondrial production of reactive oxygen species and induced mitochondrial fission. This decreases fatty acid oxidation, thus leading to the accumulation of lipid species and insulin resistance in skeletal muscle. Altogether, we propose mitochondrial dynamics as a potential target for disturbances associated with low fatty acid oxidation.
DescripciĂłn
Lugar de PublicaciĂłn
Sponsorship
CitaciĂłn
Metabolism, Vol.144, N° 155578 (2023) p. 1-8.
Palabras clave
Fatty acid oxidation, Mitochondria dynamics, Mitochondria-associated membranes, Organelle dynamics, Metabolic flexibility
Licencia
AtribuciĂłn-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)