Biomarkers of oxidative stress in maternal plasma, umbilical cord and placenta of patients with gestational diabetes: a systematic review and meta-analysis

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dc.contributor.authorEtchegaray-Armijo, Karina
dc.contributor.authorBustos-Arriagada, Edson
dc.contributor.authorNavarro-Rosenblatt, Deborah
dc.contributor.authorVera, Claudio
dc.contributor.authorGarmendia, María Luisa
dc.contributor.authorSobrevia, Luis
dc.contributor.authorLópez-Alarcón, Camilo
dc.contributor.authorCasanello, Paola
dc.coverage.spatialUSA
dc.date.accessioned2026-01-06T15:37:13Z
dc.date.available2026-01-06T15:37:13Z
dc.date.issued2025-05-06
dc.description.abstractObjective: To determine the association between Gestational Diabetes Mellitus (GDM) and oxidative stress biomarkers in the mother, placenta, and newborn. Methods: We conducted a systematic review and meta-analysis following the PRISMA guidelines. We searched PubMed/MEDLINE and the Web of Science database without language restrictions. The search was updated on December 28, 2023, and included reports published between 1998 and 2021. Two independent reviewers performed article selection and data extraction. Results: Our findings show a significant increase in malondialdehyde and 8-isoprostane levels in the maternal plasma and placenta of women with GDM compared to those without GDM (SMD [95 % CI] = 1.99 [1.51, 2.48], Tau2 = 1.51, I 2 = 94 %, p < 0.00001; SMD [95 % CI] = 1.90 [0.08, 2.72], Tau2 = 1.14, I 2 = 93 %, p < 0.00001, respectively). Additionally, there was a decrease in superoxide dismutase (SOD) levels in maternal plasma (SMD [95 % CI] = − 2.80 [-5.23, − 0.36], Tau2 = 7.56, I 2 = 98 %, p < 0.00001). However, no significant changes in SOD were observed in the placenta or the umbilical cord blood of offspring from women with GDM (SMD [95 % CI] = − 1.79 [-4.66, 1.07], Tau2 = 6.23, I 2 = 97 %, p < 0.00001; SMD [95 % CI] = − 1.07 [-3.37, 1.24], Tau2 = 5.31, I 2 = 97 %, p < 0.00001, respectively).
dc.description.sponsorshipNational Agency for Research and Development (ANID), Chile, Fondecyt 1221812 (PC), Fondecyt 1220459 (CLA), ANID-PhD scholarship 2424035 (KEA), SOCHINUT-2024 (KEA, PC, CLA). Research Directorate of the School of Medicine from the Pontificia Universidad Catolica de Chile (DIDEMUC, 220723001) (LS).
dc.identifier.citationFree Radical Biology and Medicine Vol. 237 (2025) p. 650-665.
dc.identifier.doihttps://orcid.org/0000-0002-8536-3729
dc.identifier.doihttps://orcid.org/0000-0003-4698-1425
dc.identifier.issn0891-5849
dc.identifier.urihttps://hdl.handle.net/20.500.12254/7433
dc.language.isoen
dc.publisherElsevier
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectAntioxidants
dc.subjectBiomarkers
dc.subjectGestational diabetes
dc.subjectOxidative stress
dc.subjectPlacenta
dc.subjectUmbilical cord blood
dc.titleBiomarkers of oxidative stress in maternal plasma, umbilical cord and placenta of patients with gestational diabetes: a systematic review and meta-analysis
dc.typeArticle
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