Biomarkers of oxidative stress in maternal plasma, umbilical cord and placenta of patients with gestational diabetes: a systematic review and meta-analysis

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1-s2.0-S0891584925007567-main.pdf (8.11 MB)
Fecha
2025-05-06
Nota de Acceso
Fecha de embargo
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ISSN de la revista
Título del volumen
Editor
Elsevier
ISBN
ISSN
0891-5849
ISSNe
DOI
https://orcid.org/0000-0002-8536-3729
 https://orcid.org/0000-0003-4698-1425
URI
https://hdl.handle.net/20.500.12254/7433
Resumen
Objective: To determine the association between Gestational Diabetes Mellitus (GDM) and oxidative stress biomarkers in the mother, placenta, and newborn. Methods: We conducted a systematic review and meta-analysis following the PRISMA guidelines. We searched PubMed/MEDLINE and the Web of Science database without language restrictions. The search was updated on December 28, 2023, and included reports published between 1998 and 2021. Two independent reviewers performed article selection and data extraction. Results: Our findings show a significant increase in malondialdehyde and 8-isoprostane levels in the maternal plasma and placenta of women with GDM compared to those without GDM (SMD [95 % CI] = 1.99 [1.51, 2.48], Tau2 = 1.51, I 2 = 94 %, p < 0.00001; SMD [95 % CI] = 1.90 [0.08, 2.72], Tau2 = 1.14, I 2 = 93 %, p < 0.00001, respectively). Additionally, there was a decrease in superoxide dismutase (SOD) levels in maternal plasma (SMD [95 % CI] = − 2.80 [-5.23, − 0.36], Tau2 = 7.56, I 2 = 98 %, p < 0.00001). However, no significant changes in SOD were observed in the placenta or the umbilical cord blood of offspring from women with GDM (SMD [95 % CI] = − 1.79 [-4.66, 1.07], Tau2 = 6.23, I 2 = 97 %, p < 0.00001; SMD [95 % CI] = − 1.07 [-3.37, 1.24], Tau2 = 5.31, I 2 = 97 %, p < 0.00001, respectively).
Descripción
Lugar de Publicación
USA
Sponsorship
National Agency for Research and Development (ANID), Chile, Fondecyt 1221812 (PC), Fondecyt 1220459 (CLA), ANID-PhD scholarship 2424035 (KEA), SOCHINUT-2024 (KEA, PC, CLA). Research Directorate of the School of Medicine from the Pontificia Universidad Catolica de Chile (DIDEMUC, 220723001) (LS).
Citación
Free Radical Biology and Medicine Vol. 237 (2025) p. 650-665.
Palabras clave
Antioxidants, Biomarkers, Gestational diabetes, Oxidative stress, Placenta, Umbilical cord blood
Licencia
Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
Licencia URL
http://creativecommons.org/licenses/by-nc-sa/3.0/cl/
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Artículos de Revistas