Artículos de Revistas

URI permanente para esta colección

https://repositorio.uft.cl/handle/20.500.12254/2470

Examinar

Examinando Artículos de Revistas por Materia "Antioxidants"

Mostrando 1 - 2 de 2
  • Miniatura
    Ítem
    Biomarkers of oxidative stress in maternal plasma, umbilical cord and placenta of patients with gestational diabetes: a systematic review and meta-analysis
    (Elsevier, 2025-05-06) Etchegaray-Armijo, Karina; Bustos-Arriagada, Edson; Navarro-Rosenblatt, Deborah; Vera, Claudio; Garmendia, María Luisa; Sobrevia, Luis; López-Alarcón, Camilo; Casanello, Paola
    Objective: To determine the association between Gestational Diabetes Mellitus (GDM) and oxidative stress biomarkers in the mother, placenta, and newborn. Methods: We conducted a systematic review and meta-analysis following the PRISMA guidelines. We searched PubMed/MEDLINE and the Web of Science database without language restrictions. The search was updated on December 28, 2023, and included reports published between 1998 and 2021. Two independent reviewers performed article selection and data extraction. Results: Our findings show a significant increase in malondialdehyde and 8-isoprostane levels in the maternal plasma and placenta of women with GDM compared to those without GDM (SMD [95 % CI] = 1.99 [1.51, 2.48], Tau2 = 1.51, I 2 = 94 %, p < 0.00001; SMD [95 % CI] = 1.90 [0.08, 2.72], Tau2 = 1.14, I 2 = 93 %, p < 0.00001, respectively). Additionally, there was a decrease in superoxide dismutase (SOD) levels in maternal plasma (SMD [95 % CI] = − 2.80 [-5.23, − 0.36], Tau2 = 7.56, I 2 = 98 %, p < 0.00001). However, no significant changes in SOD were observed in the placenta or the umbilical cord blood of offspring from women with GDM (SMD [95 % CI] = − 1.79 [-4.66, 1.07], Tau2 = 6.23, I 2 = 97 %, p < 0.00001; SMD [95 % CI] = − 1.07 [-3.37, 1.24], Tau2 = 5.31, I 2 = 97 %, p < 0.00001, respectively).
  • Miniatura
    Ítem
    Phlorotannins: novel orally administrated bioactive compounds that induce mitochondrial dysfunction and oxidative stress in cancer
    (MDPI, 2023-09-07) Simón, Layla; Arazo-Rusindo, Migdalia Caridad; Quest, Andrew F. G.; Mariotti-Celis, María Salomé
    Mitochondrial dysfunction is an interesting therapeutic target to help reduce cancer deaths, and the use of bioactive compounds has emerged as a novel and safe approach to solve this problem. Here, we discuss the information available related to phlorotannins, a type of polyphenol present in brown seaweeds that reportedly functions as antioxidants/pro-oxidants and anti-inflammatory and anti-tumorigenic agents. Specifically, available evidence indicates that dieckol and phloroglucinol promote mitochondrial membrane depolarization and mitochondria-dependent apoptosis. Phlorotannins also reduce pro-tumorigenic, -inflammatory, and -angiogenic signaling mechanisms involving RAS/MAPK/ERK, PI3K/Akt/mTOR, NF-κB, and VEGF. In doing so, they inhibit pathways that favor cancer development and progression. Unfortunately, these compounds are rather labile and, therefore, this review also summarizes approaches permitting the encapsulation of bioactive compounds, like phlorotannins, and their subsequent oral administration as novel and non-invasive therapeutic alternatives for cancer treatment.