Examinando por Autor "Cancino, Jorge"
Mostrando 1 - 14 de 14
Resultados por página
Opciones de ordenación
Ítem A single bout of resistance exercise triggers mitophagy, potentially involving the ejection of mitochondria in human skeletal muscle(Wiley, 2024-09-24) Díaz-Castro, Francisco; Tuñón-Suárez, Mauro; Rivera, Patricia; Botella, Javier; Cancino, Jorge; Figueroa, Ana María; Gutiérrez, Juan; Cantin, Claudette; Deldicque, Louise; Zbinden-Foncea, Hermann; Nielsen, Joachim; Henríquez-Olguín, Carlos; Morselli, Eugenia; Castro-Sepúlveda, MauricioAim The present study aimed to investigate the effects of a single bout of resistance exercise on mitophagy in human skeletal muscle (SkM). Methods Eight healthy men were recruited to complete an acute bout of one-leg resistance exercise. SkM biopsies were obtained one hour after exercise in the resting leg (Rest-leg) and the contracting leg (Ex-leg). Mitophagy was assessed using protein-related abundance, transmission electron microscopy (TEM), and fluorescence microscopy. Results Our results show that acute resistance exercise increased pro-fission protein phosphorylation (DRP1Ser616) and decreased mitophagy markers such as PARKIN and BNIP3L/NIX protein abundance in the Ex-leg. Additionally, mitochondrial complex IV decreased in the Ex-leg when compared to the Rest-leg. In the Ex-leg, TEM and immunofluorescence images showed mitochondrial cristae abnormalities, a mitochondrial fission phenotype, and increased mitophagosome-like structures in both subsarcolemmal and intermyofibrillar mitochondria. We also observed increased mitophagosome-like structures on the subsarcolemmal cleft and mitochondria in the extracellular space of SkM in the Ex-leg. We stimulated human primary myotubes with CCCP, which mimics mitophagy induction in the Ex-leg, and found that BNIP3L/NIX protein abundance decreased independently of lysosomal degradation. Finally, in another human cohort, we found a negative association between BNIP3L/NIX protein abundance with both mitophagosome-like structures and mitochondrial cristae density in the SkM. Conclusion The findings suggest that a single bout of resistance exercise can initiate mitophagy, potentially involving mitochondrial ejection, in human skeletal muscle. BNIP3L/NIX is proposed as a sensitive marker for assessing mitophagy flux in SkM.Ítem Adaptación transcultural del cuestionario para valoración del fitness cardiorrespiratorio: CLINIMEX Aerobic Fitness Questionnaire(Sociedad Chilena de Medicina del Deporte, 2025) Cancino, Jorge; Barrera-Cifuentes, María Paz; Cruz-Alaniz, Nicolás; León-Carrasco, BárbaraObjetivo: Adaptar transculturalmente al español chileno el CLINIMEX Aerobic Fitness Questionnaire para estimar el fitness cardiorrespiratorio. Métodos: Se realizó una traducción inicial por dos traductoras bilingües de lengua materna chilena y una retrotraducción por dos traductores bilingües de lengua materna portuguesa. Luego, un comité de expertos revisó el cuestionario antes de su aplicación a un primer grupo de 40 personas mayores de 18 años. Tras confirmar su comprensibilidad, se aplicó la versión final a un grupo de 20 personas. Resultados: En la primera fase, un 27,5% (n=11) tuvo dificultades con el término “hatha”, un 10% (n=4) con “spinning”, un 7,5% (n=3) con “hidrogimnasia” y un 2,5% (n=1) con “musculación”. En el segundo grupo, el fitness cardiorrespiratorio estimado fue de 10.8±2.8 METs (rango 5-16). Conclusión: Se logró la adaptación del cuestionario CLINIMEX al español chileno. Esta adaptación constituye un paso fundamental para avanzar en el proceso de validación del instrumento en nuestra población y entregar una herramienta sencilla para la valoración clínica del fitness respiratorio. Objective: To carry out the cross-cultural adaptation of the CLINIMEX Aerobic Fitness Questionnaire intoChilean Spanish for the estimation of cardiorespiratory fitness. Methods: An initial translation was performed by two bilingual translators whose native language is Chilean Spanish, followed by a back-translation by two bilingual translators whose native language is Portuguese. A committee of experts then reviewed the questionnaire before it was administered to a first group of 40 individuals aged 18 and older. After confirming its comprehensibility, the final version was administered to a second group of 20 participants. Results: In the first phase, 27.5% (n=11) had difficulties with the term “hatha,” 10% (n=4) with “spinning,” 7.5% (n=3) with “hydrogymnastics,” and 2.5% (n=1) with “strength training.” In the second group, the estimated cardiorespiratory fitness was 10.8±2.8 METs (range 5–16). Conclusion: The CLINIMEX questionnaire was successfully adapted into Chilean Spanish. This adaptation represents a key step toward the validation of the instrument in our population and provides a simple tool for the clinical assessment of cardiorespiratory fitness.Ítem Adherence to an Early Exercise Plan Promotes Visceral Fat Loss in the First Month Following Bariatric Surgery.(Springer, 2025) Pino-Zuñiga, Johanna; Lillo-Urzua, Paloma; Olivares-Galvez, Mariela; Palacio-Aguero, Ana; Duque, Juan Camilo; Luengas, Rafael; Cancino, JorgeBackground: The evidence supporting the benefits of early exercise in post-bariatric patients is growing. This study analyzed the effects of early exercise (1-week post-bariatric surgery) on body composition in patients with overweight and obesity 1 month after surgery. Methods: Thirty patients (age 36.5 ± 12.3 [range, 18-65] years; body mass index [BMI], 36.2 ± 12.3 kg/m2, range, 29-48) who underwent laparoscopic sleeve gastrectomy for bariatric surgery were instructed to participate in an exercise training program initiated on day 3 post-surgery and to follow a recommended protein intake of 60 g/day. After 1-month post-surgery, patients were stratified into those who adhered to exercise recommendations and those who did not. Pre- and post-differences in total weight loss (TWL), skeletal muscle mass (SMM), fat mass (FM), and visceral fat mass (VFM) were compared. Results: TWL, SMM, and FM loss were similar between non-adherent and adherent subjects (10.2 ± 3.5 kg and 11.9 ± 3.6 kg; p = 0.2; 2.9 ± 1.0 kg and 3.2 ± 1.2; p = 0.2; 6.2 ± 2.1 kg and 7.5 ± 3.6 kg; p = 0.2, respectively), whereas VFM was markedly reduced in the adherent group (29.9 ± 18.2 cm2 vs 14.6 ± 9.4 cm2; p = 0.01) compared to the non-adherent group. When the group was divided according to adherence to exercise and protein intake or non-adherence to both conditions, there was a significant difference in TWL, FM, and VFM losses (p < 0.05). In contrast, no differences in SMM were found. Conclusions: Early exercise training accelerated visceral fat mass loss during the initial recovery period in patients after bariatric surgery. Additionally, adherence to daily protein intake recommendations can increase total body weight and fat mass loss.Ítem Block strength training based on age-related functional consequences in older women(PLOS One, 2025) Jofré-Saldía, Emilio; Festa, Raúl Ricardo; Villalobos-Gorigoitía, Álvaro; Jorquera-Aguilera, Carlos; Ojeda, Álvaro Huerta; Cancino, Jorge; Gea-García, Gemma MaríaStrength training is a form of healthy ageing in older women. Although recommendations currently exist, some are very broad or fail to cover the needs of aging. Therefore, the purpose of this study was to analyze the effects of blocks strength training based on age-related functional consequences on functional performance in older adult women. 82 community-dwelling older women (70.17 ± 6.04 y) were randomly assigned to either experimental (n = 40) or control (n = 42) group. Experimental group performed a Block Strength Training (BST) program based on strength, power, and muscular endurance, and different level of effort for 9 weeks, and control maintained daily routine with physical activity recommendations. Functional performance was assessed using absolute handgrip strength [AHS], timed up and go [TUG], two-minutes step test [2MST], five times stand-to-sit test [5-SST], 6-m walking speed test [6-WS] pre-post intervention. Statistical analyses were performed using two-way ANOVA (Time*Group) and effect size (partial eta-squared, ŋP2) with a significance level of p < 0.05. BST improved functional performance in the protocols of AHS (21.51 vs. 23.07-kg; + 7%), TUG (8.22 vs. 7.29-sec; + 11%), 2MST (78.76 vs. 97.18-steps; + 23%), 5-SST (12.68 vs. 9.43-sec; + 26%), and 6-WS (1.16 vs. 1.36- m·s-1; + 17%) compared to control (19.31 vs. 19.66-kg; 8.94 vs. 9.26-sec; 62.68 vs. 63.73-steps; 13.99 vs. 14.25-sec; 1.06 vs. 1.06-m·s-1, respectively) in a Time*Group interaction effect (p < 0.01; ŋP2 > 0.11). This BST is effective in improving overall functional performance and thus reducing the risk of physical frailty in community-dwelling older women. These findings strengthen the approach to exercise programming over recommendations, moving toward effective precision dosing for older adults.Ítem Creatine supplementation prior to strength exercise training is not superior in preventing muscle mass loss compared with standard nutritional recommendations in females after bariatric surgery: a pilot study(Springer Nature, 2024) Díaz Pizarro, Marcelo; Pino Zúñiga, Johanna; Olivares Gálvez , Mariela; Rendón Vesga , Carolina; Luengas Tello, Rafael; Duque Seguro, Juan Camilo; Cancino, JorgeBackground: This study examines whether creatine supplementation combined with strength training mitigates muscle mass loss in women during early rehabilitation post-bariatric surgery, as its effectiveness remains untested in this context. Methods: Fifteen women (37.8 ± 9.6 years; BMI, 38.8 ± 5.6 kg/m2) completed the intervention (creatine group = 7; placebo group = 8). Both groups followed a strength training program three times a week for 8 weeks. The dosage for both the creatine and placebo was 8 g prior to each exercise session. Body weight, skeletal muscle mass, fat mass, handgrip strength, and physical activity levels were measured before and after the intervention. Results: The creatine group showed a reduction of 9.5 ± 1.5 kg in body weight, with a 0.72 ± 0.6 kg decrease in muscle mass and an 8.64 ± 1.2 kg reduction in fat mass. The placebo group had a reduction of 9.6 ± 3.5 kg in body weight, with a 0.6 ± 1.2 kg decrease in muscle mass and an 8.88 ± 3.2 kg reduction in fat mass, without significant differences between groups (p > 0.05). Conclusion: The pre-session strength exercise training creatine supplementation is not superior to placebo regarding body weight and fat mass losses and the attenuation of muscle mass loss during the first weeks of rehabilitation following bariatric surgery.Ítem Dog companionship and cortisol levels in youth. A systematic review and meta-analysis(Elsevier, 2025) Peña-Jorquera, Humberto; Hernandez-Jaña, Sam; Sanchez-Martinez, Javier; Espinoza-Puelles, Juan Pablo; Martínez-Flores, Ricardo; Barreto-Schuch, Felipe; Yañez-Seplveda, Rodrigo; Delgado-Floody, Pedro; Ferrari, Gerson; Sadarangani, Kabir P.; Cancino, Jorge; Bento-Torres, Joao; Espinoza-Salinas, Alexis; Stamatakis, Emmanuel; Cristi-Montero, CarlosObjective: Traditional and non-traditional strategies have been employed to improve youth health. Dog-assisted interventions have been proposed as a novel strategy to regulate stress and its consequences across all age groups. This systematic review and multilevel meta-analysis assessed the influence of dog-assisted interventions on cortisol levels in youth and explored potential moderators. Sources: We conducted a comprehensive systematic search across multiple databases, including PubMed, Scopus, Web of Science, Cochrane Library, and ScienceDirect, up to June 17, 2024, to evaluate the impact of dog-assisted interventions on youth cortisol levels. Two reviewers independently extracted and verified data from eligible randomized clinical trials, with a third reviewer ensuring accuracy. Cochrane's RoB 2.0 tool was used to assess the risk of bias. Heterogeneity was analyzed using Q and I2 statistics. A random-effects model was employed to calculate effect sizes (ES) using R software. Summary of the findings: Significant cortisol reductions were found for interventions lasting >15 min (ES: 0.65; p = .038), with a non-significant trend towards reduced cortisol in non-medical settings (ES: 0.46; p = .070). No significant effects were observed for shorter interventions, different control groups, or age-specific analyses. Meta-regression analysis revealed significant differences, showing better outcomes with longer intervention times and fewer female participants. Conclusion: Dog-assisted interventions lasting >15 min seem to be a promising and non-traditional strategy for regulating cortisol levels in children and adolescents in stressful situations. This study outlines gaps in the research and future directions.Ítem Early Exercise Boosts Visceral Fat Loss Post‑Bariatric Surgery in the First Month(Springer Nature, 2025) Cancino, Jorge; Lillo-Urzua, Paloma; Olivares-Galvez, Mariela; Palacio-Aguero, Ana; Duque, Juan Camilo; Luengas, Rafael; Pino-Zuñiga, JohannaThis letter to the editor addresses critiques of a clinical study evaluating the efficacy of an early, counseling-based physical exercise intervention in post-bariatric patients. The authors highlight the paucity of research regarding proactive modification of body composition within the initial postoperative month, focusing particularly on visceral adipose tissue mass. The implemented protocol consisted of a home-based, unsupervised resistance training regimen employing elastic bands, initiated between postoperative days 5 and 7, following individualized in-hospital familiarization and audiovisual instruction. The intervention demonstrated high feasibility, safety, and clinical applicability, especially for populations with limited access to direct supervision during the early postoperative period. No adverse events were reported. The significant reduction in visceral adiposity observed is underscored as a clinically relevant proxy for improved metabolic risk profile. The use of subjective scales of perceived exertion (such as the Borg Scale) is justified when objective monitoring devices are unavailable. The authors recommend that future research prioritize the identification of determinants influencing patient adherence to exercise prescription within post-bariatric rehabilitation frameworks, aiming to optimize therapeutic outcomes.Ítem Early exercise through telerehabilitation after bariatric surgery: is it feasible?(Springer, 2024) Pino Zúñiga, Johanna; Olivares, Mariela; Muñoz, Giselle; Boza, Camilo; Duque, Camilo; Cancino, JorgePurpose: The feasibility of early telerehabilitation after bariatric surgery is unknown. The objective of this study was to assess the feasibility and perception of engaging in the online exercise protocol in patients during the first month after bariatric surgery. Material and methods: A total of 67 patients, enrolled in a telerehabilitation program following bariatric surgery, completed a survey assessing their perception of the intensity, discomfort, and safety during exercise sessions. Results: Forty percent of participants began exercising between 5 and 10 days after surgery. Seventy-one percent of patients did not experience discomfort during the first month of exercise, and those who reported discomfort mainly mentioned dizziness and abdominal pain. No significant differences were found in the presence of discomfort among different types of surgeries performed. There was a significant difference in the presence of discomfort between patients who started exercising before and after 15 days of surgery, with less discomfort reported in the group that started after 15 days. Ninety-eight percent of patients felt safe during online exercise sessions. Most participants perceived the intensity of the sessions as moderate. The most frequently mentioned benefits of exercise were increased energy, mood, and feeling more active. Conclusion: Telerehabilitation conducted during the first month after bariatric surgery was feasible and well tolerated by patients, providing a safe alternative for those patients who face difficulties with in-person interventions.Ítem Effects of Maca (Lepidium meyenii Walp.) on Physical Performance in Animals and Humans: A Systematic Review and Meta-Analysis(MDPI, 2025) Huerta Ojeda, Álvaro; Rodríguez Rojas, Javiera; Cancino, Jorge; Barahona-Fuentes, Guillermo; Pavez, Leonardo; Yeomans-Cabrera, María-Mercedes; Jorquera-Aguilera, CarlosBackground: Lepidium meyenii Walp. (LmW), known as maca, has been shown to increase physical performance. However, the effect size (ES) of LmW on the different manifestations of physical performance has not yet been described. Objectives: To examine and qualitatively describe the studies published up to 2024 that employed LmW supplementation to increase physical performance in animal and human experimentation. In addition, the ES associated with the different interventions was calculated. Methods: The research followed PRISMA® guidelines for systematic reviews and meta-analyses, using Web of Science, Scopus, SPORTDiscus, PubMed, and MEDLINE databases until 2024. Randomized controlled studies with a pre- and post-test design, conducted both in vitro and in vivo in animals and humans, were included. Methodological quality assessment was performed using the CAMARADES tool for animal studies and the Newcastle Ottawa Scale for human studies. The main variables were the forced swimming test (FST), the rota-rod test (RRT), the grip strength test (GST), blood lactic acid (BLA), and lactic acid (LA). The analysis was conducted with a pooled standardized mean difference (SMD) through Hedges’ g test (95% CI). Results: Twenty-one studies were included in the systematic review and sixteen in the meta-analysis. They revealed a large effect for all outcomes (SMD: FST = 2.26, RRT = 6.26, GST = 5.23, LA = −1.01, and BLA = −1.70). Conclusions: The phytochemical compounds of LmW, mainly macamides, increase physical performance, showing a greater effect at higher doses (dose–response effect).Ítem Estimation of ventilatory thresholds during exercise using respiratory wearable sensors(Springer Nature, 2024) Contreras-Briceño, Felipe; Cancino, Jorge; Espinoza-Ramírez, Maximiliano; Fernández, Gonzalo; Johnson, Vader; Hurtado, DanielVentilatory thresholds (VTs) are key physiological parameters used to evaluate physical performance and determine aerobic and anaerobic transitions during exercise. Current assessment of these parameters requires ergospirometry, limiting evaluation to laboratory or clinical settings. In this work, we introduce a wearable respiratory system that continuously tracks breathing during exercise and estimates VTs during ramp tests. We validate the respiratory rate and VTs predictions in 17 healthy adults using ergospirometry analysis. In addition, we use the wearable system to evaluate VTs in 107 recreational athletes during ramp tests outside the laboratory and show that the mean population values agree with physiological variables traditionally used to exercise prescription. We envision that respiratory wearables can be useful in determining aerobic and anaerobic parameters with promising applications in health telemonitoring and human performance.Ítem Prescription of High-intensity aerobic interval training based on oxygen uptake kinetics(Thieme, 2023) Festa, Raúl Ricardo; Monsalves-Álvarez, Matías; Cancino, Jorge; Jannas-Vela, SebastiánEndurance training results in diverse adaptations that lead to increased performance and health benefits. A commonly measured training response is the analysis of oxygen uptake kinetics, representing the demand of a determined load (speed/work) on the cardiovascular, respiratory, and metabolic systems, providing useful information for the prescription of constant load or interval-type aerobic exercise. There is evidence that during high-intensity aerobic exercise some interventions prescribe brief interval times (<1-min), which may lead to a dissociation between the load prescribed and the oxygen uptake demanded, potentially affecting training outcomes. Therefore, this review explored the time to achieve a close association between the speed/work prescribed and the oxygen uptake demanded after the onset of high-intensity aerobic exercise. The evidence assessed revealed that at least 80% of the oxygen uptake amplitude is reached when phase II of oxygen uptake kinetics is completed (1 to 2 minutes after the onset of exercise, depending on the training status). We propose that the minimum work-time during high-intensity aerobic interval training sessions should be at least 1 minute for athletes and 2 minutes for non-athletes. This suggestion could be used by coaches, physical trainers, clinicians and sports or health scientists for the prescription of high-intensity aerobic interval training.Ítem Study protocol and rationale of "the UP project": evaluating the effectiveness of active breaks on health indicators in desk-based workers(Frontiers Media S.A., 2024) Cristi-Montero, Carlos; Martínez-Flores, Ricardo; Espinoza-Puelles, Juan Pablo; Favero-Ramirez, Laura; Zurita-Corvalan, Natalia; Castillo Cañete, Ignacio; Leppe, Jaime; Ferrari, Gerson; Sadarangani, Kabir P.; Cancino, Jorge; Hernandez-Jaña, Sam; Yuing Farias, Tuillang; Batista Lemes, Vanilson; Rodríguez-Rodríguez, Fernando; Brand, CarolineBackground: Excessive sedentary time has been negatively associated with several health outcomes, and physical activity alone does not seem to fully counteract these consequences. This panorama emphasizes the essential of sedentary time interruption programs. “The Up Project” seeks to assess the effectiveness of two interventions, one incorporating active breaks led by a professional and the other utilizing a computer application (self-led), of both equivalent duration and intensity. These interventions will be compared with a control group to evaluate their impact on physical activity levels, sedentary time, stress perception, occupational pain, and cardiometabolic risk factors among office workers. Methods: This quasi-experimental study includes 60 desk-based workers from universities and educational institutes in Valparaiso, Chile, assigned to three groups: (a) booster breaks led by professionals, (b) computer prompts that are unled, and (c) a control group. The intervention protocol for both experimental groups will last 12 weeks (only weekdays). The following measurements will be performed at baseline and post-intervention: cardiometabolic risk based on body composition (fat mass, fat-free mass, and bone mass evaluated by DXA), waist circumference, blood pressure, resting heart rate, and handgrip strength. Physical activity and sedentary time will be self-reported and device-based assessed using accelerometry. Questionnaires will be used to determine the perception of stress and occupational pain. Discussion: Governments worldwide are addressing health issues associated with sedentary behavior, particularly concerning individuals highly exposed to it, such as desk-based workers. Despite implementing certain strategies, there remains a noticeable gap in comprehensive research comparing diverse protocols. For instance, studies that contrast the outcomes of interventions led by professionals with those prompted by computers are scarce. This ongoing project is expected to contribute to evidence-based interventions targeting reduced perceived stress levels and enhancing desk-based employees’ mental and physical well-being. The implications of these findings could have the capacity to lay the groundwork for future public health initiatives and government-funded programs.Ítem Submaximal Accentuated Eccentric Jump Training Improves Punching Performance and Countermovement Jump Force–Time Variables in Amateur Boxers(MDPI, 2025) Sánchez-Ramírez, Celso; Cid-Calfucura, Izham; Hernandez-Martinez, Jordan; Cancino, Jorge; Aedo-Muñoz, Esteban; Valdés-Badilla, Pablo; Franchini, Emerson; García-García, José Manuel; Calvo-Rico, Bibiana; Abián-Vicén, Javier; Herrera-Valenzuela, TomásObjective: This study aimed to identify the effects of a submaximal jump training program using accentuated eccentric loading (AEL) on punching performance and countermovement jump (CMJ) force–time characteristics in amateur boxers. Methods: Twenty-nine amateur boxers (age: 24.9 ± 5.4 years; height of 175.9 ± 5.2 cm; body mass: 76.2 ± 10.5 kg) were randomly assigned to three groups: AEL group (n = 9), CMJ group (n = 10), and control group (n = 10). The AEL group performed countermovement jumps using handheld dumbbells equivalent to 10–20% of body mass, followed by unloaded concentric phases. All participants were evaluated pre- and post-intervention on punching peak force and countermovement jump performance. Results: Significant differences were found in favor of the AEL group for the peak force of the jab punch (pre: 1050 ± 203; post: 1158 ± 189 N), straight punch (pre: 1685 ± 393; post: 1861 ± 429 N), right cross punch (pre: 2005 ± 362; post: 2150 ± 417 N), and left cross punch (pre: 1836 ± 312; post: 1977 ± 393 N), along with greater gains in jump height, propulsive impulse, and absolute and relative peak power than the CMJ and control groups. Conclusions: A submaximal accentuated eccentric jump training program enhances punching peak force and lower-limb power output in amateur boxers, offering a practical strategy for improving power-oriented performance during preparatory training phases.Ítem The effects of maca (lepidium meyenii walp) on cellular oxidative stress: a systematic review and meta-analysis(MDPI, 2024-08-28) Huerta Ojeda, Álvaro; Rodríguez Rojas, Javiera; Cuevas Guíñez, Jorge; Ciriza Velásquez, Stephanie; Cancino, Jorge; Barahona Fuentes, Guillermo; Yeomans Cabrera, María Mercedes; Pavez, Leonardo; Jorquera Aguilera, CarlosLepidium meyenii Walp (LmW) or Maca, including its bioactive components such as macamides, among others, has demonstrated antioxidant effects. However, the effect size (ES) of LmW on oxidative stress has not been qualitatively described and calculated. The primary objective of this systematic review and meta-analysis was to review and qualitatively describe the studies published up to 2023 that supplemented LmW to control cellular oxidative stress; the secondary objective was to calculate the ES of the different interventions. The search was designed following the PRISMA® guidelines for systematic reviews and meta-analyses and performed in the Web of Science, Scopus, SPORTDiscus, PubMed, and MEDLINE until 2023. The selection of studies included randomized controlled trials, with tests and post-tests, both in vitro and in vivo in animals and humans. The methodological quality and risk of bias were evaluated with the CAMARADES tool. The main variables were reduced glutathione, glutathione peroxidase, superoxide dismutase, and malondialdehyde. The analysis was conducted with a pooled standardized mean difference (SMD) through Hedges’ g test (95% CI). Eleven studies were included in the systematic review and eight in the meta-analysis. They revealed a small effect for reduced glutathione (SMD = 0.89), a large effect for glutathione peroxidase (SMD = 0.96), a moderate effect for superoxide dismutase (SMD = 0.68), and a moderate effect for malondialdehyde (SMD = −0.53). According to the results, the phytochemical compounds of LmW effectively controlled cellular oxidative stress, mainly macamides. It was also determined that a higher dose of LmW generated a greater antioxidant effect. However, information concerning humans is scarce.