The effects of maca (lepidium meyenii walp) on cellular oxidative stress: a systematic review and meta-analysis

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antioxidants.pdf (2.37 MB)
Fecha
2024-08-28
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Profe guía
Perfil ORCID
https://orcid.org/0000-0003-3620-9861
Título de la revista
ISSN de la revista
Título del volumen
Editor
MDPI
ISBN
ISSN
2076-3921
ISSNe
DOI
https://doi.org/10.3390/antiox13091046
URI
http://hdl.handle.net/20.500.12254/4016
Resumen
Lepidium meyenii Walp (LmW) or Maca, including its bioactive components such as macamides, among others, has demonstrated antioxidant effects. However, the effect size (ES) of LmW on oxidative stress has not been qualitatively described and calculated. The primary objective of this systematic review and meta-analysis was to review and qualitatively describe the studies published up to 2023 that supplemented LmW to control cellular oxidative stress; the secondary objective was to calculate the ES of the different interventions. The search was designed following the PRISMA® guidelines for systematic reviews and meta-analyses and performed in the Web of Science, Scopus, SPORTDiscus, PubMed, and MEDLINE until 2023. The selection of studies included randomized controlled trials, with tests and post-tests, both in vitro and in vivo in animals and humans. The methodological quality and risk of bias were evaluated with the CAMARADES tool. The main variables were reduced glutathione, glutathione peroxidase, superoxide dismutase, and malondialdehyde. The analysis was conducted with a pooled standardized mean difference (SMD) through Hedges’ g test (95% CI). Eleven studies were included in the systematic review and eight in the meta-analysis. They revealed a small effect for reduced glutathione (SMD = 0.89), a large effect for glutathione peroxidase (SMD = 0.96), a moderate effect for superoxide dismutase (SMD = 0.68), and a moderate effect for malondialdehyde (SMD = −0.53). According to the results, the phytochemical compounds of LmW effectively controlled cellular oxidative stress, mainly macamides. It was also determined that a higher dose of LmW generated a greater antioxidant effect. However, information concerning humans is scarce.
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Citación
Antioxidants, Vol. 13, N°1046 (2024) p. 1-28.
Palabras clave
Brassicaceae, In vitro techniques, Cell tracking, Free radicals, Oxidative stress
Licencia
Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
Licencia URL
http://creativecommons.org/licenses/by-nc-sa/3.0/cl/
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Artículos de Revistas