Repositorio Institucional
Sistema de Bibliotecas Universidad Finis Terrae
El Repositorio Institucional de la Universidad FinisTerrae, es gestionado por el Sistema de Bibliotecas y tiene por objetivo permitir el acceso libre a la producción académica e institucional de la Universidad, aumentando la visibilidad de sus contenidos y garantizando su conservación.
Envíos recientes
Propuestas para reducir las listas de espera odontológica: Mesa de Consenso sobre la Lista de Espera Odontológica: Metodología Delphi adaptada
(Universidad Finis Terrae, 2025) Caro, Juan Carlos; Moya, Patricia; Zamorano Vidal, Sebastián; Ponce Ibáñez, Nicolás
Presentar las propuestas consensuadas por un panel de 14 expertos nacionales e internacionales para abordar una de las principales urgencias en salud pública: la crítica de las listas de espera odontológicas en Chile. Este informe busca motivar la acción legislativa y ejecutiva para revertir décadas de rezago en salud bucal.
Muscle-specific AXIN1 and AXIN2 double knockout does not alter AMPK/mTORC1 signalling or glucose metabolism
(Wiley; The Physiological Society, 2025-07-01) Persson, Kaspar W.; Meneses-Valdés, Roberto; Andersen, Nicoline R.; Pedersen, Frederik S.; Gallo, Samantha; Hesselager, Sofie A.; Henríquez-Olguín, Carlos; Jensen, Thomas E.
AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) are crucial kinase signalling hubs that regulate the balance between catabolism and anabolism in skeletal muscle. The scaffold protein AXIN1 has been proposed to regulate the switch between these pathways and be required for GLUT4 translocation in skeletal muscle and adipocyte cell lines. Muscle-specific AXIN1 knockout (KO) mice exhibit no discernable phenotype, possibly due to compensation by AXIN2 upon AXIN1 loss. Thus we generated and characterized muscle-specific inducible AXIN1 and AXIN2 double knockout (dKO) mice. Surprisingly AXIN1/2 dKO mice displayed normal AMPK and mTORC1 signalling and glucose uptake in response to 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), insulin and in situ muscle contraction. These findings suggest that AXIN proteins are not essential for the regulation of AMPK and mTORC1 signalling or glucose uptake in skeletal muscle. This study challenges the previously indicated critical roles of AXIN1 in exercise-stimulated AMPK activation and GLUT4-mediated glucose uptake in skeletal muscle. KEY POINTS: Phenotyping of tamoxifen-inducible muscle-specific AXIN1/2 double knockout (dKO) mice. We find no evidence for AXIN-dependent AMPK or mTORC1 regulation in skeletal muscle by insulin, AMPK activation or contraction. Glucose uptake regulation by insulin and AMPK activation is normal in AXIN1/2 dKO mice.
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
(Elsevier, 0022-06-25) Chubanava, Sabina; Karavaeva, Iuliia; Ehrlich, Amy M.; Justicia, Roger M.; Basse, Astrid L.; Kulik, Ivan; Dalbram, Emilie; Ahwazi, Danial; Heaselgrave, Samuel R.; Trost, Kajetan; Stocks, Ben; Hodek, Ondrej; Rodrigues, Raissa N.; Havelund, Jesper F.; Schlabs, Farina L.; Larsen, Steen; Yonamine, Caio Y.; Henríquez-Olguín, Carlos; Giustarini, Daniela; Rossi, Ranieri; Gerhart-Hines, Zachary; Moritz, Thomas; Zierath, Juleen R.; Sakamoto, Kei; Jensen, Thomas E.; Færgeman, Nils J.; Lavery, Gareth G.; Deshmukh, Atul S.; Treebak, Jonas T.
Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numerous regulatory proteins. Dysregulations of NAD metabolism are widely regarded as detrimental to health, with NAD depletion commonly implicated in aging. However, the extent to which cellular NAD concentration can decline without adverse consequences remains unclear. To investigate this, we generated a mouse model in which nicotinamide phosphoribosyltransferase (NAMPT)-mediated NAD+ biosynthesis was disrupted in adult skeletal muscle. The intervention resulted in an 85% reduction in muscle NAD+ abundance while maintaining tissue integrity and functionality, as demonstrated by preserved muscle morphology, contractility, and exercise tolerance. This absence of functional impairments was further supported by intact mitochondrial respiratory capacity and unaltered muscle transcriptomic and proteomic profiles. Furthermore, lifelong NAD depletion did not accelerate muscle aging or impair whole-body metabolism. Collectively, these findings suggest that NAD depletion does not contribute to age-related decline in skeletal muscle function.
Holismo semántico y metáforas: estructura, contexto y variación interpretativa
(Universidade Federal do Recôncavo da Bahia, 2025) Dantas Freitas Estrela, Kênio Angelo
This article combines Lakoff and Johnson’s conceptual metaphor theory with Henry Jackman’s moderate semantic holism to offer a more precise understanding of figurative language as a situated semantic phenomenon. It argues that, while conceptual metaphor theory provides a coherent framework for explaining systematicity, it tends to underestimate interpretive variability and the role of discursive context. In contrast, moderate holism conceives metaphorical meaning as a many-to-one function, locally stabilized within partially shared belief networks. Through a theoretical review and the analysis of three metaphors drawn from contemporary Spanish—related to running, teaching, and emotional life—the article shows that figurative interpretation does not follow fixed rules or literal substitutions, but rather emerges from situated communicative practices. This approach broadens the scope of figurative meaning studies from an interdisciplinary perspective, combining philosophical and linguistic tools with special attention to context.
This article combines Lakoff and Johnson’s conceptual metaphor theory with Henry Jackman’s moderate semantic holism to offer a more precise understanding of figurative language as a situated semantic phenomenon. It argues that, while conceptual metaphor theory provides a coherent framework for explaining systematicity, it tends to underestimate interpretive variability and the role of discursive context. In contrast, moderate holism conceives metaphorical meaning as a many-to-one function, locally stabilized within partially shared belief networks. Through a theoretical review and the analysis of three metaphors drawn from contemporary Spanish—related to running, teaching, and emotional life—the article shows that figurative interpretation does not follow fixed rules or literal substitutions, but rather emerges from situated communicative practices. This approach broadens the scope of figurative meaning studies from an interdisciplinary perspective, combining philosophical and linguistic tools with special attention to context.
Las máquinas de mirar: el teleorama como dispositivo pedagógico
(RU Books Recolectores Urbanos; Universitat Politécnica de Catalunya, 2025) Carrasco Purull, Gonzalo; Salvatierra Meza, Belén
En este capítulo se presenta una experiencia docente desarrollada en el marco de la asignatura Arquitectura antigua y la tradición clásica, en la que se implementaron metodologías basadas en tecnologías inmersivas. A partir del concepto de “máquinas de mirar”, se exploraron las posibilidades críticas de los dispositivos ópticos y de la representación arquitectónica mediante el uso del teleorama como herramienta para analizar las imágenes producidas por Karl Friedrich Schinkel y PaulMarie Letarouilly. El alumnado trabajó en la identificación de planos de profundidad y en la construcción de artefactos que reproducían las perspectivas originales. La propuesta metodológica incentivó tanto el empleo de tecnologías digitales como una reflexión crítica sobre el impacto de las imágenes en la formación arquitectónica contemporánea. Los resultados evidenciaron la necesidad de plantear nuevas formas de comprensión de la imagen en el ámbito de la enseñanza de la arquitectura.