Efecto del consumo de curcumina sobre la inflamación y estrés oxidativo en pacientes con hemodiálisis
Date
2022
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Universidad Finis Terrae (Chile) Facultad de Medicina
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Abstract
La Enfermedad Renal Crónica (ERC) conlleva a un estatus de microinflamación basal y oxidación que se exacerba en estadios avanzados de la enfermedad. Esto está originado principalmente por la acumulación de desechos metabólicos tóxicos como urea y creatinina, y también debido a otras patologías basales. Los pacientes con ERC en estadio 5 requieren de Terapias de Reemplazo Renal (TRR) para eliminar las toxinas y productos de desecho de la sangre, entre las cuales se encuentra la Hemodiálisis (HD). Durante la terapia dialítica, existe un proceso de uremia nefasta que produce principalmente la inflamación. A eso se adiciona la técnica de depuración sanguínea extracorpórea, en la cual si los filtros presentan membranas que no son biocompatibles y el agua no es ultrapura, aumenta la inflamación por esta causa, lo que puede conllevar a la acumulación de moléculas de gran peso molecular.
En este sentido, el consumo de compuestos bioactivos con propiedades antiinflamatorias y antioxidantes, tales como la curcumina; ha demostrado eficacia en la disminución de indicadores plasmáticos de inflamación y oxidación en pacientes con diversas patologías crónicas. Lo cual sugiere que su ingesta habitual puede contribuir, en alguna medida, a atenuar esta condición en los pacientes con HD.
La presente revisión bibliográfica recopila, analiza y discute la evidencia científica disponible respecto al efecto de la ingesta de curcumina sobre la inflamación y estrés oxidativo de pacientes con HD, integrando la biodisponibilidad del bioactivo como la principal fuerza motriz de su efectividad. El documento aborda la temática considerando tres aristas fundamentales: (i) inflamación y estrés oxidativo en pacientes con HD, (ii) efecto de la ingesta de curcumina sobre la inflamación y estrés oxidativo e (iii) influencia de la biodisponibilidad de la curcumina sobre su efectividad. Esto contribuirá a la ejecución de intervenciones nutricionales que validen la eficacia y seguridad de la suplementación de curcumina como parte de la dietoterapia en la HD.
Chronic Kidney Disease (CKD) causes a microinflammatory and oxidative status that is exacerbated in advanced stages of the disease. This is mainly caused by the accumulation of toxic metabolic wastes such as urea and creatinine, and also due to other basal pathologies. Patients with stage 5 CKD require Renal Replacement Therapies (RRT) to remove toxins and waste products from the blood, including Hemodialysis (HD). During dialysis therapy, there is a harmful uremia process, which mainly produces inflammation. To this is added the extracorporeal blood purification technique, in which if the filters have membranes that are not biocompatible and the water is not ultrapure, inflammation increases due to this cause, which can lead to the accumulation of molecules of high molecular weight. In this regard, the consumption of bioactive compounds with anti-inflammatory and antioxidant properties, such as curcumin, has been shown to be effective in reducing plasma markers of inflammation and oxidation in patients with various chronic pathologies. This suggests that its regular intake may contribute, to some extent, to attenuate this condition in HD patients. This literature review compiles, analyzes and discusses the available scientific evidence on the effect of curcumin intake on inflammation and oxidative stress in HD patients, integrating the bioavailability of the bioactive as the main driver of its efficacy. The paper approaches the subject considering three fundamental aspects: (i) inflammation and oxidative stress in HD patients, (ii) the effect of curcumin intake on inflammation and oxidative stress and (iii) the influence of curcumin bioavailability on its efficacy. This will contribute to the implementation of nutritional interventions that validate the efficacy and safety of curcumin supplementation as part of dietary therapy in HD.
Chronic Kidney Disease (CKD) causes a microinflammatory and oxidative status that is exacerbated in advanced stages of the disease. This is mainly caused by the accumulation of toxic metabolic wastes such as urea and creatinine, and also due to other basal pathologies. Patients with stage 5 CKD require Renal Replacement Therapies (RRT) to remove toxins and waste products from the blood, including Hemodialysis (HD). During dialysis therapy, there is a harmful uremia process, which mainly produces inflammation. To this is added the extracorporeal blood purification technique, in which if the filters have membranes that are not biocompatible and the water is not ultrapure, inflammation increases due to this cause, which can lead to the accumulation of molecules of high molecular weight. In this regard, the consumption of bioactive compounds with anti-inflammatory and antioxidant properties, such as curcumin, has been shown to be effective in reducing plasma markers of inflammation and oxidation in patients with various chronic pathologies. This suggests that its regular intake may contribute, to some extent, to attenuate this condition in HD patients. This literature review compiles, analyzes and discusses the available scientific evidence on the effect of curcumin intake on inflammation and oxidative stress in HD patients, integrating the bioavailability of the bioactive as the main driver of its efficacy. The paper approaches the subject considering three fundamental aspects: (i) inflammation and oxidative stress in HD patients, (ii) the effect of curcumin intake on inflammation and oxidative stress and (iii) the influence of curcumin bioavailability on its efficacy. This will contribute to the implementation of nutritional interventions that validate the efficacy and safety of curcumin supplementation as part of dietary therapy in HD.
Description
Tesis (Licenciada en Nutrición y Dietética)--Universidad Finis Terrae, 2022
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Santiago, Chile
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Citation
Keywords
INSUFICIENCIA RENAL CRONICA, DIETOTERAPIA, ESTRÉS OXIDATIVO, TESIS DIGITAL
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Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)