Similar metabolic health in overweight/obese individuals with contrasting metabolic flexibility to an oral glucose tolerance test

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Similar metabolic health in overweight obese individuals with contrasting metabolic flexibility to an oral glucose tolerance test.pdf (5.52 MB)
Date
2021-11-16
Authors
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0000-0002-5948-2281
 https://doi.org/10.3389/fnut.2021.745907
Journal Title
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Publisher
Frontiers Media
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2296-861X
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URI
http://hdl.handle.net/20.500.12254/2120
Abstract
Background: Low metabolic flexibility (MetF) may be an underlying factor for metabolic health impairment. Individuals with low MetF are thus expected to have worse metabolic health than subjects with high MetF. Therefore, we aimed to compare metabolic health in individuals with contrasting MetF to an oral glucose tolerance test (OGTT). Methods: In individuals with excess body weight, we measured MetF as the change in respiratory quotient (RQ) from fasting to 1 h after ingestion of a 75-g glucose load (i.e., OGTT). Individuals were then grouped into low and high MetF (Low-MetF n = 12; HighMetF n = 13). The groups had similar body mass index, body fat, sex, age, and maximum oxygen uptake. Metabolic health markers (clinical markers, insulin sensitivity/resistance, abdominal fat, and intrahepatic fat) were compared between groups. Results: Fasting glucose, triglycerides (TG), and high-density lipoprotein (HDL) were similar between groups. So were insulin sensitivity/resistance, visceral, and intrahepatic fat. Nevertheless, High-MetF individuals had higher diastolic blood pressure, a larger drop in TG concentration during the OGTT, and a borderline significant (P = 0.05) higher Subcutaneous Adipose Tissue (SAT). Further, compared to Low-MetF, High-MetF individuals had an about 2-fold steeper slope for the relationship between SAT and fat mass index. Conclusion: Individuals with contrasting MetF to an OGTT had similar metabolic health. Yet High-MetF appears related to enhanced circulating TG clearance and enlarged subcutaneous fat.
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The work was funded by ANID/CONICYT FONDECYT Iniciación (11180361 to RF-V), and ANID/CONICYT FONDECYT Regular (1170117 to JG).
Citation
Fernández-Verdejo R, Malo-Vintimilla L, Gutiérrez-Pino J, López-Fuenzalida A, Olmos P, Irarrazaval P and Galgani JE (2021) Similar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test. Front. Nutr. 8:745907. doi: 10.3389/fnut.2021.745907
Keywords
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Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
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http://creativecommons.org/licenses/by-nc-sa/3.0/cl/
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