Similar metabolic health in overweight/obese individuals with contrasting metabolic flexibility to an oral glucose tolerance test

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dc.contributor.authorFernández-Verdejo, Rodrigo
dc.contributor.authorMalo-Vintimilla, Lorena
dc.contributor.authorGutiérrez-Pino, Juan
dc.contributor.authorLópez-Fuenzalida, Antonio
dc.contributor.authorOlmos, Pablo
dc.contributor.authorIrarrazaval, Pablo
dc.contributor.authorGalgani, Jose E.
dc.date.accessioned2021-12-15T12:46:54Z
dc.date.available2021-12-15T12:46:54Z
dc.date.issued2021-11-16
dc.description.abstractBackground: Low metabolic flexibility (MetF) may be an underlying factor for metabolic health impairment. Individuals with low MetF are thus expected to have worse metabolic health than subjects with high MetF. Therefore, we aimed to compare metabolic health in individuals with contrasting MetF to an oral glucose tolerance test (OGTT). Methods: In individuals with excess body weight, we measured MetF as the change in respiratory quotient (RQ) from fasting to 1 h after ingestion of a 75-g glucose load (i.e., OGTT). Individuals were then grouped into low and high MetF (Low-MetF n = 12; HighMetF n = 13). The groups had similar body mass index, body fat, sex, age, and maximum oxygen uptake. Metabolic health markers (clinical markers, insulin sensitivity/resistance, abdominal fat, and intrahepatic fat) were compared between groups. Results: Fasting glucose, triglycerides (TG), and high-density lipoprotein (HDL) were similar between groups. So were insulin sensitivity/resistance, visceral, and intrahepatic fat. Nevertheless, High-MetF individuals had higher diastolic blood pressure, a larger drop in TG concentration during the OGTT, and a borderline significant (P = 0.05) higher Subcutaneous Adipose Tissue (SAT). Further, compared to Low-MetF, High-MetF individuals had an about 2-fold steeper slope for the relationship between SAT and fat mass index. Conclusion: Individuals with contrasting MetF to an OGTT had similar metabolic health. Yet High-MetF appears related to enhanced circulating TG clearance and enlarged subcutaneous fat.en
dc.description.sponsorshipThe work was funded by ANID/CONICYT FONDECYT Iniciación (11180361 to RF-V), and ANID/CONICYT FONDECYT Regular (1170117 to JG).es
dc.identifier.citationFrontiers in Nutrition, Vol. 8, N° 745907 (2021)es
dc.identifier.doihttps://doi.org/10.3389/fnut.2021.745907
dc.identifier.issn2296-861X
dc.identifier.orcidhttps://orcid.org/0000-0002-5948-2281
dc.identifier.urihttp://hdl.handle.net/20.500.12254/2120
dc.language.isoenen
dc.publisherFrontiers Media S.A.en
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subject.otherCarbohydrate metabolismen
dc.subject.otherInsulin sensitivityen
dc.subject.otherInsulin resistanceen
dc.subject.otherLipid metabolismen
dc.subject.otherFuel selectionen
dc.titleSimilar metabolic health in overweight/obese individuals with contrasting metabolic flexibility to an oral glucose tolerance testen
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