Driving hypertension: non-classic apparent mineralocorticoid excess
Fecha
2025-11-12
Nota de Acceso
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Título del volumen
Editor
Springer Nature
ISBN
ISSN
1759-5029
ISSNe
1759-5037
Resumen
Non-classic apparent mineralocorticoid excess is an underrecognized cause of low-renin hypertension, which is often misdiagnosed as essential hypertension. This condition challenges traditional classifications and highlights the need for mechanism-based diagnostics and medical care.
Hypertension remains a leading contributor to global cardiovascular morbidity and mortality. It has a high prevalence, low rate of identifiable causes and is frequently resistant to conventional therapy. Hypertension is traditionally classified as ‘essential’ and multifactorial; however, up to one-third of patients have hypertension with a low-renin phenotype . This subtype has been largely attributed to primary aldosteronism, yet emerging data suggest a broader and more complex spectrum of mineralocorticoid receptor (MR) overactivation. Non-classic apparent mineralocorticoid excess (NC-AME) is one of several overlooked contributors to low-renin hypertension; NC-AME might account for a meaningful proportion of patients who have been misclassified as having essential hypertension.
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Sponsorship
The authors acknowledge the support of grants ANID-FONDECYT 1212006 (C.A.C.), ICM-ANID, ICN2021_045 (C.A.C., C.E.F.), 11251675 (A.T.-C.), ANILLO ACT 210039 (R.B.), SOCHED 2024-06 (A.T.-C.) and CETREN-UC 2024 (C.A.C., C.E.F.).
Citación
Nature Reviews Endocrinology, (2025) p. 1-2.
Palabras clave
Apparent mineralocorticoid excess, Hypertension, Low-renin hypertension
Licencia
Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)