Driving hypertension: non-classic apparent mineralocorticoid excess

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dc.contributor.authorCarvajal, Cristian A.
dc.contributor.authorTapia-Castillo, Alejandra
dc.contributor.authorUslar, Thomas
dc.contributor.authorVaidya, Anand
dc.contributor.authorPérez, Jorge A.
dc.contributor.authorBaudrand, Rene
dc.contributor.authorFardella, Carlos E.
dc.date.accessioned2025-11-27T19:07:55Z
dc.date.available2025-11-27T19:07:55Z
dc.date.issued2025-11-12
dc.description.abstractNon-classic apparent mineralocorticoid excess is an underrecognized cause of low-renin hypertension, which is often misdiagnosed as essential hypertension. This condition challenges traditional classifications and highlights the need for mechanism-based diagnostics and medical care. Hypertension remains a leading contributor to global cardiovascular morbidity and mortality. It has a high prevalence, low rate of identifiable causes and is frequently resistant to conventional therapy. Hypertension is traditionally classified as ‘essential’ and multifactorial; however, up to one-third of patients have hypertension with a low-renin phenotype . This subtype has been largely attributed to primary aldosteronism, yet emerging data suggest a broader and more complex spectrum of mineralocorticoid receptor (MR) overactivation. Non-classic apparent mineralocorticoid excess (NC-AME) is one of several overlooked contributors to low-renin hypertension; NC-AME might account for a meaningful proportion of patients who have been misclassified as having essential hypertension.
dc.description.sponsorshipThe authors acknowledge the support of grants ANID-FONDECYT 1212006 (C.A.C.), ICM-ANID, ICN2021_045 (C.A.C., C.E.F.), 11251675 (A.T.-C.), ANILLO ACT 210039 (R.B.), SOCHED 2024-06 (A.T.-C.) and CETREN-UC 2024 (C.A.C., C.E.F.).
dc.identifier.citationNature Reviews Endocrinology, (2025) p. 1-2.
dc.identifier.doihttps://doi.org/10.1038/s41574-025-01209-6
dc.identifier.issn1759-5029
dc.identifier.issne1759-5037
dc.identifier.orcidhttps://orcid.org/0000-0002-6081-1468
dc.identifier.urihttps://hdl.handle.net/20.500.12254/7374
dc.language.isoen
dc.publisherSpringer Nature
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectApparent mineralocorticoid excess
dc.subjectHypertension
dc.subjectLow-renin hypertension
dc.titleDriving hypertension: non-classic apparent mineralocorticoid excess
dc.typeArticle
dcterms.accessRightsEl artículo no puede ser publicado en el Repositorio Institucional debido a los permisos de copyright definidos por la editorial publicadora. Diríjase al DOI.
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