Puesta al día: carcinoma paratiroideo
Fecha
2021
Profe guía
Perfil ORCID
Título de la revista
ISSN de la revista
Título del volumen
Editor
Sociedad Médica de Santiago; Sociedad Chilena de Medicina Interna
ISBN
ISSN
0034-9887
ISSNe
Resumen
Parathyroid carcinoma is a rare malignant disease that presents as a sporadic or familial primary hyperparathyroidism (PHP). The latter is associated with some genetic syndromes. It occurs with equal frequency in both sexes, unlike PHP caused by parathyroid adenoma that is more common in women. It hould be suspected in cases of severe hypercalcemia, with high parathyroid hormone levels and a palpable cervical mass.
Given the difficulty in distinguishing between parathyroid carcinoma and adenoma prior to the surgery, the diagnosis is often made after parathyroidectomy. The only curative treatment is complete surgical resection with oncologic block resection of the primary tumor to ensure free margins. Adjuvant therapies with chemotherapy or radiation therapy do not modify overall or disease-free survival. Recurrences are common and re-operation of resectable recurrent disease is recommended. The palliative treatment of symptomatic hypercalcemia is crucial in persistent or recurrent disease after surgery since morbidity and mortality are more associated with hypercalcemia than with tumor burden.
Descripción
Lugar de Publicación
Sponsorship
Citación
Revista Médica de Chile, Vol. 149, N° 3 (2021) p. 399-408.
Palabras clave
Licencia
Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)