Vitamin D status and obesity in children from Chile

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dc.contributor.authorPérez-Bravo, Franciscoes
dc.contributor.authorDuarte, Lissettees
dc.contributor.authorArredondo-Olguín, Migueles
dc.contributor.authorIñiguez, Germánes
dc.contributor.authorCastillo-Valenzuela, Oscares
dc.coverage.spatialChilees
dc.date.accessioned2021-12-10T14:07:39Z
dc.date.available2021-12-10T14:07:39Z
dc.date.issued2021
dc.description.abstractBACKGROUND: Vitamin D [25(OH)D] is essential for normal bone development and maintenance. Furthermore, its deficiency has been associated with obesity, cardiovascular diseases, insulin resistance, autoimmune diseases, and certain cancers. OBJECTIVE: To determine the incidence of serum 25(OH)D deficiency (<20 ng/ml) among apparently healthy Chilean children (4–14 years old) from three Chilean geographic areas during May–September 2018. MATERIALS AND METHODS: Serum 25(OH)D levels were measured by a competitive protein-binding ELISA assay in 1134 children, and correlations between serum 25(OH)D levels, BMI, and geographic area were calculated. Individuals were grouped according to their serum 25-hydroxyvitamin D levels (ng/ml): severe deficiency: <5; moderate deficiency: 5–10.9; mild deficiency: 11–20.9; insufficiency: 21–29.9 and sufficiency: 30–100. RESULTS: We found 80.4% of children had serum 25(OH)D deficiency, with 1.7% severe, 24.6% moderate, and 54.1% mild. In the three cities, the percentage of serum 25(OH)D deficit was increased when comparing overweight or obesity with a healthy weight. Additionally, an interaction effect was observed between geographic area, nutritional status, and serum 25(OH)D levels using the factorial ANOVA test (p = 0.038). In Antofagasta, there were more overweight children and also a higher percentage of children with VitD deficiency (<30 ng/ml) compared to Santiago or Concepción. CONCLUSION: This study revealed a high prevalence of serum 25(OH)D deficiency in children between 4 and 14 years old in Chile (80.4%) during May–September 2018. Obese and overweight children had the highest prevalence of serum 25(OH)D deficiency.en
dc.identifier.citationEuropean Journal of Clinical Nutrition, Vol. 76, N° 6 (2021) p. 899-901en
dc.identifier.issn1476-5640
dc.identifier.orcid0000-0002-4411-8655es
dc.identifier.orcidhttps://doi.org/10.1038/s41430-021-01043-9
dc.identifier.urihttp://hdl.handle.net/20.500.12254/2090
dc.language.isoenes
dc.publisherSpringer Naturees
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/en
dc.subject.otherVitamin D statusen
dc.subject.other25-hydroxyvitamin Den
dc.subject.otherhealthy childrenen
dc.subject.otherHealthy childrenen
dc.subject.otherAdolescentsen
dc.subject.otherVitamin D 33 deficiencyen
dc.subject.otherSun exposureen
dc.titleVitamin D status and obesity in children from Chileen
dc.typeArtículoes
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