Global respiratory syncytial virus–related infant community deaths

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dc.contributor.authorMazur, Natalie I.
dc.contributor.authorLöwensteyn, Yvette N.
dc.contributor.authorWillemsen, Joukje E.
dc.contributor.authorGill, Christopher J.
dc.contributor.authorForman, Leah
dc.contributor.authorMwananyanda, Lawrence M.
dc.contributor.authorBlau, Dianna M.
dc.contributor.authorBreiman, Robert F.
dc.contributor.authorMadhi, Shabir A.
dc.contributor.authorMahtab, Sana
dc.contributor.authorGurley, Emily S.
dc.contributor.authorEl Arifeen, Shams
dc.contributor.authorAssefa, Nega
dc.contributor.authorG. Scott, J. Anthony
dc.contributor.authorOnyango, Dickens
dc.contributor.authorTippet Barr, Beth A
dc.contributor.authorL. Kotloff, Karen
dc.contributor.authorO. Sow, Samba
dc.contributor.authorMandomando, Inacio
dc.contributor.authorOgbuanu, Ikechukwu
dc.contributor.authorJambai, Amara
dc.contributor.authorBassat, Quique
dc.contributor.authorCaballero, Mauricio T.
dc.contributor.authorPolack, Fernando P.
dc.contributor.authorOmer, Saad
dc.contributor.authorAbdul Momin Kazi
dc.contributor.authorEric A. F. Simões
dc.contributor.authorSatav, Ashish
dc.contributor.authorJ. Bont, Louis
dc.contributor.authorRSV GOLD collaborators Franco Diaz
dc.date.accessioned2021-12-17T14:35:05Z
dc.date.available2021-12-17T14:35:05Z
dc.date.issued2021
dc.descriptionTrabajo multicéntrico internacional. Universidad Finis Terrae esta listada como colaboradoraes
dc.description.abstractBackground. Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. Methods. The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. Results. We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8−3.3) was lower than in-hospital (2.4 months; IQR: 1.5−4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001). Conclusions. We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.es
dc.description.sponsorshipRSV-GOLD Respiratory Syncytial Virus Global online database.es
dc.identifier.citationClin Infect Dis. 2021;73:S229–37.es
dc.identifier.issn1537-6591
dc.identifier.orcid0000-0003-4763-074Xes
dc.identifier.orcidDOI: 10.1093/cid/ciab528
dc.identifier.urihttp://hdl.handle.net/20.500.12254/2158
dc.language.isoenes
dc.publisherOxford University Presses
dc.relation.ispartofseriesClinical Infectious Diseases;73. Suppl. 3
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subject.otherpediatricses
dc.subject.otherInfant Mortalityes
dc.subject.otherRSVes
dc.subject.otherpneumoniaes
dc.subject.otherCommunity deathes
dc.subject.otherLower respiratoryes
dc.subject.otherTract infectiones
dc.subject.otherRespiratory syncytial viruses
dc.titleGlobal respiratory syncytial virus–related infant community deathses
dc.typeArtículoes
dcterms.accessRightsEl artículo completo no puede ser publicado en el Repositorio Institucional debido a los permisos de copyright definidos por la editorial publicadora
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