Global respiratory syncytial virus–related infant community deaths

Fecha
2021
Autores
Profe guía
Perfil ORCID
0000-0003-4763-074X
 DOI: 10.1093/cid/ciab528
Título de la revista
ISSN de la revista
Título del volumen
Editor
Oxford University Press
ISBN
ISSN
1537-6591
ISSNe
DOI
URI
http://hdl.handle.net/20.500.12254/2158
Resumen
Background. Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. Methods. The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. Results. We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8−3.3) was lower than in-hospital (2.4 months; IQR: 1.5−4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001). Conclusions. We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.
Descripción
Trabajo multicéntrico internacional. Universidad Finis Terrae esta listada como colaboradora
Lugar de Publicación
Sponsorship
RSV-GOLD Respiratory Syncytial Virus Global online database.
Citación
Clin Infect Dis. 2021;73:S229–37.
Palabras clave
Licencia
Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
Licencia URL
http://creativecommons.org/licenses/by-nc-sa/3.0/cl/
Colecciones
Artículos de Revistas