Classic and “non-classic” apparent mineralocorticoid excess

Baudrand, Rene; Carvajal, Cristian; Tapia-Castillo, Alejandra; Uslar, Thomas; Fardella, Carlos

Classic and “non-classic” apparent mineralocorticoid excess

dc.contributor.author	Baudrand, Rene
dc.contributor.author	Carvajal, Cristian
dc.contributor.author	Tapia-Castillo, Alejandra
dc.contributor.author	Uslar, Thomas
dc.contributor.author	Fardella, Carlos
dc.date.accessioned	2026-02-23T18:51:11Z
dc.date.available	2026-02-23T18:51:11Z
dc.date.issued	2025
dc.description.abstract	Hypertension is highly prevalent in the general population. Up to 1/3 of patients display low-renin levels due to aldosterone-mediated mineralocorticoid receptor (MR) activation or cortisol-mediated MR activation. The spectrum of cortisol-mediated MR activation includes the classic apparent mineralocorticoid excess (AME), Cushing syndrome or milder (non-classic) forms of AME, the latter with a much higher prevalence and subtle phenotype. Classic AME is a rare autosomal recessive disorder caused by the presence of a severe dominant autosomal deficiency of 11bHSD2 gene. Non-classic -AME (NC-AME) is mainly associated with partial 11bHSD2 deficiency due to milder genetic variations or epigenetic modifications plus potential actions of endogenous or exogenous inhibitors. Treatment aims to ameliorate MR activation with low-sodium diet and MR antagonists.
dc.identifier.citation	En: Padiporn Limumpornpetch, Paul M. Stewart (editores). Encyclopedia of Endocrine Diseases. Elsevier, 2019. p. 638-643
dc.identifier.doi	https://doi.org/10.1016/B978-0-12-801238-3.64338-6
dc.identifier.isbn	9780128122006
dc.identifier.orcid	https://orcid.org/0000-0002-6081-1468
dc.identifier.uri	https://hdl.handle.net/20.500.12254/7457
dc.language.iso	en
dc.publisher	Elsevier
dc.rights	Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.title	Classic and “non-classic” apparent mineralocorticoid excess
dc.type	Book chapter
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