Morphological differences between patient self-inflicted and ventilator-induced lung injury: an experimental study

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dc.contributor.authorDíaz, Franco
dc.date.accessioned2024-07-09T13:53:12Z
dc.date.available2024-07-09T13:53:12Z
dc.date.issued2023-03
dc.description.abstractThe role of supraphysiological airway pressure and VT in lung damage during mechanical ventilation (MV) has been studied in-depth, the phenomenon called ventilator-induced lung injury (VILI). Following the same principles, strenuous pontaneous breathing can also be harmful, and the concept of patient self-inflicted lung injury (P-SILI) is proposed (1). However, establishing P-SILI as a pathological entity in acute patients is challenging. There are few P-SILI models focusing on the respiratory effort during MV, showing histological damage in animals with intense respiratory effort (2–4). On the contrary, data regarding strong unassisted spontaneous breathing without MV is lacking. Therefore, we aimed to compare the histopathological findings in animals with acute lung injury (ALI) treated without ventilatory support, injurious MV, and protective MV.
dc.identifier.citationAmerican Journal of Respiratory and Critical Care Medicine, Vol 207, N° 6 (2023) p. 780-783
dc.identifier.doihttps://doi.org/10.1164/rccm.202207-1360LE
dc.identifier.issn1073-449X
dc.identifier.issne1535-4970
dc.identifier.orcidhttps://orcid.org/0000-0003-4763-074Xes
dc.identifier.urihttp://hdl.handle.net/20.500.12254/3770
dc.language.isoenes
dc.publisherAmerican Thoracic Society
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectP-SILIes
dc.subjectVILIes
dc.subjectARDSes
dc.subjectLung mechanics
dc.subjectMechanical ventilation
dc.subjectLesión pulmonar inducida por ventilación mecánica
dc.subject.otherMechanical Ventilationes
dc.subject.otherP-SILIes
dc.subject.otherVILIes
dc.titleMorphological differences between patient self-inflicted and ventilator-induced lung injury: an experimental study
dc.typeArtículoes
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