Morphological differences between patient self-inflicted and ventilator-induced lung injury: an experimental study
Date
2023-03
Authors
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Journal Title
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Volume Title
Publisher
American Thoracic Society
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1073-449X
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1535-4970
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Abstract
The role of supraphysiological airway pressure and VT in lung damage during mechanical ventilation (MV) has been studied in-depth, the phenomenon called ventilator-induced lung injury (VILI). Following the same principles, strenuous pontaneous breathing can also be harmful, and the concept of patient self-inflicted lung injury (P-SILI) is proposed (1). However, establishing P-SILI as a pathological entity in acute patients is challenging. There are few P-SILI models focusing on the respiratory effort during MV, showing histological damage in animals with intense respiratory effort (2–4). On the contrary, data regarding strong unassisted spontaneous breathing without MV is lacking. Therefore, we aimed to compare the histopathological findings in animals with acute lung injury (ALI) treated without ventilatory support, injurious MV, and protective MV.
Description
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Citation
American Journal of Respiratory and Critical Care Medicine, Vol 207, N° 6 (2023) p. 780-783
Keywords
P-SILI, VILI, ARDS, Lung mechanics, Mechanical ventilation, Lesión pulmonar inducida por ventilación mecánica
item.page.dc.rights
Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)