Niveles séricos de Proteína C Reactiva, Interleuquina 6 y Factor de Necrosis Tumoral Alfa en pacientes con diagnóstico de periodontitis crónica leve-severa: una revisión sistemática
Date
2022
item.contributor.advisor
item.page.orcidurl
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Finis Terrae (Chile) Facultad de Odontología
item.page.isbn
item.page.issn
item.page.issne
item.page.doiurl
Abstract
Introducción: Las enfermedades cardiovasculares (ECV) son la principal causa de mortalidad a nivel mundial, y su génesis y gravedad pueden ser influenciadas por otras condiciones que provoquen un estado inflamatorio en el organismo, como la Periodontitis. La respuesta inflamatoria sistémica conlleva al aumento de los niveles de biomarcadores inflamatorios de daño cardiovascular como la Proteína C Reactiva (PCR), Factor de Necrosis Tumoral Alfa (TNF-α) e Interleuquina 6 (IL-6), contribuyendo indirectamente a la aterogénesis o a efectos cardiovasculares adversos. Objetivo: Determinar el nivel sérico de mediadores inflamatorios (PCR, IL-6 y TNF-α) en pacientes con Periodontitis leve versus pacientes con Periodontitis severa.
Materiales y Métodos: Para la elaboración de esta revisión se lograron identificar un total de 118 artículos publicados en las bases de datos Pubmed, Cochrane Library, Epistemonikos, EBSCOhost y/o Sagepub, de los cuales solo 9 estudios cumplieron con todos los criterios de elegibilidad para la síntesis cualitativa.
Resultados: Se encontraron 8 estudios de cohorte, de los cuales 5 sugieren que el diagnóstico de Periodontitis crónica severa genera un aumento de biomarcadores inflamatorios como la PCR, IL-6 y TNF-α, pudiendo potenciar el estrés oxidativo y la disfunción endotelial, conllevando así a la aparición de fenómenos ateroscleróticos.
Conclusiones: De acuerdo con la evidencia analizada, los individuos con Periodontitis crónica severa presentan mayores niveles de PCR, IL-6 y TNF-α y junto con ello, mayor probabilidad de desarrollar eventos cardiovasculares a futuro.
Background: Cardiovascular diseases (CVD) are the main cause of mortality worldwide, and their genesis and severity can be influenced by other conditions that cause an inflammatory state in the body, such as Periodontitis. The systemic inflammatory response leads to increase levels of inflammatory biomarkers of cardiovascular damage such as C-Reactive Protein (CRP), Tumor Necrosis Factor Alpha (TNF-α) and Interleukin 6 (IL-6), indirectly contributing to atherogenesis or adverse cardiovascular effects. Objective: To determine the serum level of inflammatory mediators (CRP, IL-6 and TNF-α) in patients with mild Periodontitis versus patients with severe Periodontitis. Materials and Methods: For the preparation of this review, a total of 118 articles published in the Pubmed, Cochrane Library, Epistemonikos, EBSCOhost and/or Sagepub databases were identified, of which only 9 studies met all the eligibility criteria for qualitative synthesis. Results: Eight cohort studies were found, of which five suggest that the diagnosis of severe chronic periodontitis generates an increase in inflammatory biomarkers such as CRP, IL-6 and TNF-α, which may potentiate oxidative stress and endothelial dysfunction, thus leading to the appearance of atherosclerotic phenomena. Conclusions: According to the evidence, individuals with severe chronic periodontitis present higher levels of CRP, IL-6, and TNF-α, and along with this, a greater probability of developing cardiovascular events in the future.
Background: Cardiovascular diseases (CVD) are the main cause of mortality worldwide, and their genesis and severity can be influenced by other conditions that cause an inflammatory state in the body, such as Periodontitis. The systemic inflammatory response leads to increase levels of inflammatory biomarkers of cardiovascular damage such as C-Reactive Protein (CRP), Tumor Necrosis Factor Alpha (TNF-α) and Interleukin 6 (IL-6), indirectly contributing to atherogenesis or adverse cardiovascular effects. Objective: To determine the serum level of inflammatory mediators (CRP, IL-6 and TNF-α) in patients with mild Periodontitis versus patients with severe Periodontitis. Materials and Methods: For the preparation of this review, a total of 118 articles published in the Pubmed, Cochrane Library, Epistemonikos, EBSCOhost and/or Sagepub databases were identified, of which only 9 studies met all the eligibility criteria for qualitative synthesis. Results: Eight cohort studies were found, of which five suggest that the diagnosis of severe chronic periodontitis generates an increase in inflammatory biomarkers such as CRP, IL-6 and TNF-α, which may potentiate oxidative stress and endothelial dysfunction, thus leading to the appearance of atherosclerotic phenomena. Conclusions: According to the evidence, individuals with severe chronic periodontitis present higher levels of CRP, IL-6, and TNF-α, and along with this, a greater probability of developing cardiovascular events in the future.
Description
Tesis (Cirujano Dentista)--Universidad Finis Terrae, 2022
item.page.coverage.spatial
Santiago, Chile
item.page.sponsorship
Citation
Keywords
PERIODONTITIS, ENFERMEDADES CARDIOVASCULARES
item.page.dc.rights
Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)