Mitochondria-SR interaction and mitochondrial fusion/fission in the regulation of skeletal muscle metabolism

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dc.contributor.authorCastro-Sepulveda, Mauricio
dc.contributor.authorFernández-Verdejo, Rodrigo
dc.contributor.authorZbinden-Foncea, Hermann
dc.contributor.authorRieusset, Jennifer
dc.date.accessioned2024-11-28T14:59:43Z
dc.date.available2024-11-28T14:59:43Z
dc.date.issued2023-07-01
dc.description.abstractMitochondria-endoplasmic/sarcoplasmic reticulum (ER/SR) interaction and mitochondrial fusion/fission are critical processes that influence substrate oxidation. This narrative review summarizes the evidence on the effects of substrate availability on mitochondrial-SR interaction and mitochondria fusion/fission dynamics to modulate substrate oxidation in human skeletal muscle. Evidence shows that an increase in mitochondria-SR interaction and mitochondrial fusion are associated with elevated fatty acid oxidation. In contrast, a decrease in mitochondria-SR interaction and an increase in mitochondrial fission are associated with an elevated glycolytic activity. Based on the evidence reviewed, we postulate two hypotheses for the link between mitochondrial dynamics and insulin resistance in human skeletal muscle. First, glucose and fatty acid availability modifies mitochondria-SR interaction and mitochondrial fusion/fission to help the cell to adapt substrate oxidation appropriately. Individuals with an impaired response to these substrate challenges will accumulate lipid species and develop insulin resistance in skeletal muscle. Second, a chronically elevated substrate availability (e.g. overfeeding) increases mitochondrial production of reactive oxygen species and induced mitochondrial fission. This decreases fatty acid oxidation, thus leading to the accumulation of lipid species and insulin resistance in skeletal muscle. Altogether, we propose mitochondrial dynamics as a potential target for disturbances associated with low fatty acid oxidation.
dc.identifier.citationMetabolismo, Vol.144, N° 155578 (2023) p. 1-8.
dc.identifier.doihttps://doi.org/10.1016/j.metabol.2023.155578
dc.identifier.issn0026-0495
dc.identifier.issne1532-8600
dc.identifier.orcidhttps://orcid.org/0000-0002-2270-299X
dc.identifier.orcidhttps://orcid.org/0000-0002-9643-1037
dc.identifier.urihttp://hdl.handle.net/20.500.12254/3938
dc.language.isoen
dc.publisherElsevier
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectFatty acid oxidation
dc.subjectMitochondria dynamics
dc.subjectMitochondria-associated membranes
dc.subjectOrganelle dynamics
dc.subjectMetabolic flexibility
dc.titleMitochondria-SR interaction and mitochondrial fusion/fission in the regulation of skeletal muscle metabolism
dc.typeArticle
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