The role of the circadian clock in regulating mitochondrial dynamics and their impact on skeletal muscle function and metabolism
Fecha
2025-06-25
Nota de Acceso
Fecha de embargo
Profe guía
Título de la revista
ISSN de la revista
Título del volumen
Editor
The Physiological Society
ISBN
ISSN
0022-3751
ISSNe
1469-7793
Resumen
Disruptions in both circadian clock and mitochondrial dynamics in the skeletal muscle (SkM) have been associated with insulin resistance and sarcopenia. Emerging evidence, in resting conditions and in response to metabolic challenges like exercise, suggests the intricate interplay between the circadian clock, mitochondrial dynamics and SkM function. However the molecular mechanisms that connect the circadian clock to mitochondrial dynamics and SkM function remain poorly understood. This review focuses on the role of circadian clock proteins, particularly brain and muscle Arnt-like protein-1 (BMAL1), in regulating mitochondrial dynamics and examines how their dysregulation contributes to metabolic and SkM deterioration. By exploring their interaction we aim to identify potential therapeutic targets that could improve metabolic health and muscle function.
Descripción
Lugar de Publicación
Sponsorship
This work was supported by ANID/FONDECYT Iniciación 11230548 to M.C.-S.
Citación
The Journal of Physiology, (2025) p. 1-15.
Palabras clave
Circadian clock, Insulin resistance, Metabolism, Mitochondrial dynamics, Sarcopenia, Skeletal muscle
Licencia
Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)