The role of the circadian clock in regulating mitochondrial dynamics and their impact on skeletal muscle function and metabolism

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dc.contributor.authorCarriel-Nesvara, Alfonso
dc.contributor.authorMuñoz-Medina, Cristóbal
dc.contributor.authorDeldicque, Louise
dc.contributor.authorCastro-Sepúlveda, Mauricio
dc.date.accessioned2025-09-25T12:51:21Z
dc.date.available2025-09-25T12:51:21Z
dc.date.issued2025-06-25
dc.description.abstractDisruptions in both circadian clock and mitochondrial dynamics in the skeletal muscle (SkM) have been associated with insulin resistance and sarcopenia. Emerging evidence, in resting conditions and in response to metabolic challenges like exercise, suggests the intricate interplay between the circadian clock, mitochondrial dynamics and SkM function. However the molecular mechanisms that connect the circadian clock to mitochondrial dynamics and SkM function remain poorly understood. This review focuses on the role of circadian clock proteins, particularly brain and muscle Arnt-like protein-1 (BMAL1), in regulating mitochondrial dynamics and examines how their dysregulation contributes to metabolic and SkM deterioration. By exploring their interaction we aim to identify potential therapeutic targets that could improve metabolic health and muscle function.
dc.description.sponsorshipThis work was supported by ANID/FONDECYT Iniciación 11230548 to M.C.-S.
dc.identifier.citationThe Journal of Physiology, (2025) p. 1-15.
dc.identifier.doihttps://doi.org/10.1113/JP289019
dc.identifier.issn0022-3751
dc.identifier.issne1469-7793
dc.identifier.orcidhttps://orcid.org/0009-0002-0205-4478
dc.identifier.orcidhttps://orcid.org/0009-0000-2165-0553
dc.identifier.orcidhttps://orcid.org/0000-0002-2270-299X
dc.identifier.urihttps://hdl.handle.net/20.500.12254/4311
dc.language.isoen
dc.publisherThe Physiological Society
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectCircadian clock
dc.subjectInsulin resistance
dc.subjectMetabolism
dc.subjectMitochondrial dynamics
dc.subjectSarcopenia
dc.subjectSkeletal muscle
dc.titleThe role of the circadian clock in regulating mitochondrial dynamics and their impact on skeletal muscle function and metabolism
dc.typeArticle
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