The effects of maca (lepidium meyenii walp) on cellular oxidative stress: a systematic review and meta-analysis

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dc.contributor.authorHuerta Ojeda, Álvaro
dc.contributor.authorRodríguez Rojas, Javiera
dc.contributor.authorCuevas Guíñez, Jorge
dc.contributor.authorCiriza Velásquez, Stephanie
dc.contributor.authorCancino, Jorge
dc.contributor.authorBarahona Fuentes, Guillermo
dc.contributor.authorYeomans Cabrera, María Mercedes
dc.contributor.authorPavez, Leonardo
dc.contributor.authorJorquera Aguilera, Carlos
dc.date.accessioned2024-12-18T18:39:47Z
dc.date.available2024-12-18T18:39:47Z
dc.date.issued2024-08-28
dc.description.abstractLepidium meyenii Walp (LmW) or Maca, including its bioactive components such as macamides, among others, has demonstrated antioxidant effects. However, the effect size (ES) of LmW on oxidative stress has not been qualitatively described and calculated. The primary objective of this systematic review and meta-analysis was to review and qualitatively describe the studies published up to 2023 that supplemented LmW to control cellular oxidative stress; the secondary objective was to calculate the ES of the different interventions. The search was designed following the PRISMA® guidelines for systematic reviews and meta-analyses and performed in the Web of Science, Scopus, SPORTDiscus, PubMed, and MEDLINE until 2023. The selection of studies included randomized controlled trials, with tests and post-tests, both in vitro and in vivo in animals and humans. The methodological quality and risk of bias were evaluated with the CAMARADES tool. The main variables were reduced glutathione, glutathione peroxidase, superoxide dismutase, and malondialdehyde. The analysis was conducted with a pooled standardized mean difference (SMD) through Hedges’ g test (95% CI). Eleven studies were included in the systematic review and eight in the meta-analysis. They revealed a small effect for reduced glutathione (SMD = 0.89), a large effect for glutathione peroxidase (SMD = 0.96), a moderate effect for superoxide dismutase (SMD = 0.68), and a moderate effect for malondialdehyde (SMD = −0.53). According to the results, the phytochemical compounds of LmW effectively controlled cellular oxidative stress, mainly macamides. It was also determined that a higher dose of LmW generated a greater antioxidant effect. However, information concerning humans is scarce.
dc.identifier.citationAntioxidants, Vol. 13, N°1046 (2024) p. 1-28.
dc.identifier.doihttps://doi.org/10.3390/antiox13091046
dc.identifier.issn2076-3921
dc.identifier.orcidhttps://orcid.org/0000-0003-3620-9861
dc.identifier.urihttp://hdl.handle.net/20.500.12254/4016
dc.language.isoen
dc.publisherMDPI
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectBrassicaceae
dc.subjectIn vitro techniques
dc.subjectCell tracking
dc.subjectFree radicals
dc.subjectOxidative stress
dc.titleThe effects of maca (lepidium meyenii walp) on cellular oxidative stress: a systematic review and meta-analysis
dc.typeArticle
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