Thyme essential oil loaded microspheres for fish fungal infection: microstructure, in vitro dynamic release and antifungal activity

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dc.contributor.authorBenavides, Sergioes
dc.contributor.authorMariotti-Celis, María Salomées
dc.contributor.authorParedes, Maria Jose Carolinaes
dc.contributor.authorParada, Javier A.es
dc.contributor.authorFranco, Wendy V.es
dc.date.accessioned2021-12-14T12:33:41Z
dc.date.available2021-12-14T12:33:41Z
dc.date.issued2020-09-25
dc.description.abstractAims: Evaluate the effect of varying the droplet size of microspheres charged with thyme essen tial oil (TEO-MS) on their swelling (Sw), release rate (%RR) and in vitro antifungal activity against Saprolegnia sp. Methods: TEO-MS obtained by ionic gelation were characterised through SEM microscopy and X-ray microtomography. Their Sw and RR% were evaluated at simulated fish-gastrointestinal conditions using gravimetric and spectrophotometric techniques. Results: For all evaluated droplet sizes (p 0.05), TEO was heterogeneously distributed inside of the MS and TEO-MS experimented agglomeration and sphericity loss after the drying process. Under gastric conditions, the acid pH (2.9) limited the Sw (50–100%) of TEO-MS, generating a low RR% (14–18%). Contrary, the slightly alkaline intestinal pH (8.1) favoured the Sw ( 3.2 to 3.8 times) and therefore the RR% (42–63%). Conclusions: TEO-MS (5–100 mg/mL) presented antifungal capacity onto Saprolegnia sp. after the simulated fish digestion, being the small droplet size once the most effective.en
dc.identifier.citationJournal of Microencapsulation, Vol. 38 N° 1 (2021) p. 11-21en
dc.identifier.issn1464-5246
dc.identifier.orcidDOI: https://doi.org/10.1080/02652048.2020.1836055es
dc.identifier.orcidhttps://orcid.org/ 0000-0002-3646-8540es
dc.identifier.urihttp://hdl.handle.net/20.500.12254/2094
dc.language.isoenes
dc.publisherTaylor & Francis Onlineen
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/en
dc.subject.otherMicrosphereses
dc.subject.otherEssential oiles
dc.subject.otherMicrostructurees
dc.subject.otherAntifungal capacityes
dc.titleThyme essential oil loaded microspheres for fish fungal infection: microstructure, in vitro dynamic release and antifungal activityes
dc.typeArtículoes
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