Thyme essential oil loaded microspheres for fish fungal infection: microstructure, in vitro dynamic release and antifungal activity

Benavides, Sergio; Mariotti-Celis, María Salomé; Paredes, Maria Jose Carolina; Parada, Javier A.; Franco, Wendy V.

Thyme essential oil loaded microspheres for fish fungal infection: microstructure, in vitro dynamic release and antifungal activity

dc.contributor.author	Benavides, Sergio	es
dc.contributor.author	Mariotti-Celis, María Salomé	es
dc.contributor.author	Paredes, Maria Jose Carolina	es
dc.contributor.author	Parada, Javier A.	es
dc.contributor.author	Franco, Wendy V.	es
dc.date.accessioned	2021-12-14T12:33:41Z
dc.date.available	2021-12-14T12:33:41Z
dc.date.issued	2020-10-13
dc.description.abstract	Aims: Evaluate the effect of varying the droplet size of microspheres charged with thyme essen tial oil (TEO-MS) on their swelling (Sw), release rate (%RR) and in vitro antifungal activity against Saprolegnia sp. Methods: TEO-MS obtained by ionic gelation were characterised through SEM microscopy and X-ray microtomography. Their Sw and RR% were evaluated at simulated fish-astrointestinal conditions using gravimetric and spectrophotometric techniques. Results: For all evaluated droplet sizes (p 0.05), TEO was heterogeneously distributed inside of the MS and TEO-MS experimented agglomeration and sphericity loss after the drying process. Under gastric conditions, the acid pH (2.9) limited the Sw (50–100%) of TEO-MS, generating a low RR% (14–18%). Contrary, the slightly alkaline intestinal pH (8.1) favoured the Sw ( 3.2 to 3.8 times) and therefore the RR% (42–63%). Conclusions: TEO-MS (5–100 mg/mL) presented antifungal capacity onto Saprolegnia sp. after the simulated fish digestion, being the small droplet size once the most effective.	en
dc.identifier.citation	Journal of Microencapsulation, Vol. 38, N° 1 (2021) p. 11-21	en
dc.identifier.doi	https://doi.org/10.1080/02652048.2020.1836055
dc.identifier.issn	1464-5246
dc.identifier.orcid	https://orcid.org/0000-0003-1357-812X
dc.identifier.uri	http://hdl.handle.net/20.500.12254/2094
dc.language.iso	en	en
dc.publisher	Taylor & Francis Online	en
dc.rights	Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/cl/	en
dc.subject.other	Microspheres	en
dc.subject.other	Essential oil	en
dc.subject.other	Microstructure	en
dc.subject.other	Antifungal capacity	en
dc.title	Thyme essential oil loaded microspheres for fish fungal infection: microstructure, in vitro dynamic release and antifungal activity	en
dc.type	Artículo	es