Photophysical characterization of tetrahydroxyphenyl porphyrin Zn(II) and V(IV) complexes: experimental and DFT study

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dc.contributor.authorDiaz-Uribe, Carlos
dc.contributor.authorRangel, Daily
dc.contributor.authorVallejo, William
dc.contributor.authorValle, Roger
dc.contributor.authorHidago-Rosa, Yoan
dc.contributor.authorZarate, Ximena
dc.contributor.authorSchott, Eduardo
dc.date.accessioned2024-02-01T17:41:40Z
dc.date.available2024-02-01T17:41:40Z
dc.date.issued2023-06-21
dc.description.abstractPhotodynamic therapy (PDT) is a promising technique for the treatment of various diseases. In this sense, the singlet oxygen quantum yield (Φ∆) is a physical–chemical property that allows to stablish the applicability of a potential photosensitizers (PS) as a drug for PDT. In the herein report, the Φ∆ of three photosensitizers was determined: metal-free tetrahydroxyphenyl porphyrin (THPP), THPP-Zn and the THPP-V metal complexes. Their biological application was also evaluated. Therefore, the in vitro study was carried out to assess their biological activity against Escherichia coli. The metal-porphyrin complexes exhibited highest activities against the bacterial strain Escherichia coli. at the highest concentration (175 μg/mL) and show better activity than the free base ligand (salts and blank solution). Results indicated a relation between Φ∆ and the inhibitory activity against Escherichia coli, thus, whereas higher is the Φ∆, higher is the inhibitory activity. The values of the Φ∆ and the inhibitory activity follows the tendency THPP-Zn > THPP > THPP-V. Furthermore, quantum chemical calculations allowed to gain deep insight into the electronic and optical properties of THPP-Zn macrocycle, which let to verify the most probable energy transfer pathway involved in the singlet oxygen generation.es
dc.identifier.citationBiometals: an international journal on the role of metal ions in biology, biochemistry, and medicine, Vol. 36 (2023) p. 1257-1272.
dc.identifier.doihttps://doi.org/10.1007/s10534-023-00514-9
dc.identifier.issn0966-0844 (print)
dc.identifier.issn1572-8773 (online)
dc.identifier.orcid0000-0002-1391-435Xes
dc.identifier.urihttp://hdl.handle.net/20.500.12254/3606
dc.language.isoenes
dc.publisherSpringer Nature
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectPorphyrins
dc.subjectPhotosensitizer
dc.subjectMetalloporphyrins
dc.subjectTerapia fotodinámica
dc.subject.otherPorphyrins · Metalloporphyrins · DFT · Escherichia coli · Photosensitizeres
dc.titlePhotophysical characterization of tetrahydroxyphenyl porphyrin Zn(II) and V(IV) complexes: experimental and DFT studyes
dc.typeArtículoes
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