Targeting mitochondria for the prevention and treatment of nonalcoholic fatty liver disease: polyphenols as a non-pharmacological approach

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dc.contributor.authorZapata, Jaime
dc.contributor.authorCastro-Sepulveda, Mauricio
dc.contributor.authorSoto-Alarcon, Sandra
dc.contributor.authorAlvarez, Daniela
dc.contributor.authorBustamante, Andres
dc.contributor.authorVillarroel, Guiselle
dc.contributor.authorGallardo, Arturo
dc.contributor.authorFernando García, Diego
dc.contributor.authorValenzuela, Rodrigo
dc.contributor.authorEcheverria, Francisca
dc.date.accessioned2024-11-27T18:46:13Z
dc.date.available2024-11-27T18:46:13Z
dc.date.issued2022-11-08
dc.description.abstractScope: Nonalcoholic fatty liver disease (NAFLD) has a high and growing prevalence globally. Mitochondria are fundamental in regulating cell energy homeostasis. Nevertheless, mitochondria control mechanisms can be exceeded in this context of energy overload. Damaged mitochondria worsen NAFLD progression. Diet and lifestyle changes are the main recommendations for NAFLD prevention and treatment. Some polyphenols have improved mitochondrial function in different NAFLD and obesity models. Objective: The study aims to discuss the potential role of polyphenols as a nonpharmacological approach targeting mitochondria to prevent and treat NAFLD, analyzing the influence of polyphenols' chemical structure, limitations and clinical projections. Methods: In vivo and in vitro NAFLD models were considered. Study searches were performed using the following keywords: nonalcoholic fatty liver disease, liver steatosis, mitochondria, mitochondrial activity, mitochondrial dynamics, mitochondrial dysfunction, mitochondrial morphology, mitochondrial cristae, fusion, fission, polyphenols, flavonoids, anthocyanins, AND/OR bioactive compounds. Conclusion: Polyphenols are a group of diverse bioactive molecules whose bioactive effects are highly determined by their chemical structure. These bioactive compounds could offer an interesting non-pharmacological approach to preventing and treating NAFLD, regulating mitochondrial dynamics and function. Nevertheless, the mitochondria' role in subjects with NAFLD treatment is not fully elucidated. The dosage and bioavailability of these compounds should be addressed when studied.
dc.identifier.citationCurrent Medicinal Chemistry, Vol.30 N°26 (2022) p. 1-19.
dc.identifier.doihttps:// doi.org/10.2174/0929867329666221007115809
dc.identifier.issn0929-8673
dc.identifier.issne1875-533X
dc.identifier.orcidhttps://orcid.org/0000-0002-2270-299X
dc.identifier.urihttp://hdl.handle.net/20.500.12254/3933
dc.language.isoen
dc.publisherBentham Science Publishers
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectBioactive compounds
dc.subjectLiver steatosis
dc.subjectMitochondrial dysfunction
dc.subjectObesity
dc.subjectPhenolic compounds
dc.titleTargeting mitochondria for the prevention and treatment of nonalcoholic fatty liver disease: polyphenols as a non-pharmacological approach
dc.typeArticle
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