The PRECISE framework: a structured approach to antibiogram interpretation for antimicrobial optimization at the bedside

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dc.contributor.authorPérez-Oliva, Claudio
dc.contributor.authorGiglio, Andrés
dc.contributor.authorMarcio Borges-Sa
dc.coverage.spatialEspaña
dc.date.accessioned2026-09-07T15:58:41Z
dc.date.available2026-09-07T15:58:41Z
dc.date.issued2026-08-31
dc.description.abstractResumen: Antimicrobial resistance claimed an estimated 4.95 million lives in 2019. When clinicians prescribe empiric therapy that follows guidelines, mortality drops by roughly a third; when they de-escalate on the basis of culture results, it drops by more than half. Yet the document that should drive both decisions, the antibiogram, is often read superficially or misinterpreted, particularly by physicians without infectious-disease training. Existing stewardship frameworks address prescribing principles, timing, or ecological impact, but none walks the clinician step by step through an individual susceptibility report and out the other side with a treatment plan. PRECISE is a seven-step mnemonic designed for that purpose. Each letter corresponds to a clinical action: Pathogen assessment, Resistance phenotype interpretation, Evaluate MIC, Curtail spectrum, Individualize PK/PD, Switch route, and Endpoint optimization. Three clinical vignettes (including one in which the steps deliberately collide) illustrate how the framework operates in practice.
dc.description.embargo30/09/2026
dc.identifier.citationRevista Española de Quimioterapia, Vol. 39, N° 5 (2026) pp. 1-11
dc.identifier.doihttps://doi.org/10.37201/req/235.2026
dc.identifier.issn0214-3429
dc.identifier.orcidhttps://orcid.org/0000-0002-0533-4531
dc.identifier.urihttps://hdl.handle.net/20.500.12254/7732
dc.language.isoen
dc.publisherSociedad Española de Quimioterapia
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectAnti-bacterial agents
dc.subjectAntimicrobial stewardship
dc.subjectMicrobial sensitivity tests
dc.subjectDrug resistance
dc.subjectBacterial
dc.subjectSepsis
dc.subjectClinical decision-making
dc.titleThe PRECISE framework: a structured approach to antibiogram interpretation for antimicrobial optimization at the bedside
dc.typeArticle
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