Reduced C-reactive protein levels after root canal treatment  in clinically healthy young apical periodontitis individuals  at cardiovascular risk. A prospective study

Garrido, Mauricio; Bordagaray, María José; Schweitzer, Catalina; Lucero-Mora, Joaquín; Reyes, Montserrat; Pellegrini, Elizabeth; Hernández-Ríos, Patricia; Fernández, Alejandra; Hernández, Marcela

Reduced C-reactive protein levels after root canal treatment in clinically healthy young apical periodontitis individuals at cardiovascular risk. A prospective study

dc.contributor.author	Garrido, Mauricio; Bordagaray, María José; Schweitzer, Catalina; Lucero-Mora, Joaquín; Reyes, Montserrat; Pellegrini, Elizabeth; Hernández-Ríos, Patricia; Fernández, Alejandra; Hernández, Marcela
dc.date.accessioned	2024-02-01T18:32:47Z
dc.date.available	2024-02-01T18:32:47Z
dc.date.issued	2024-01-05
dc.description.abstract	Aim: To determine the systemic inflammatory burden, including hsCRP and its monomeric forms, in patients with apical lesions of endodontic origin treated with root canal treatment (RCT). Methodology: Prospective pre-/post-study. Apical periodontitis (AP) individuals aged 16–40 were included (N=29). Individuals received RCT and were followed at 1 and 6months. Fasting blood samples were obtained. Apical lesions of endodon tic origin (ALEO) diameter (mm), and periapical index (PAI), were recorded. The serum concentrations of total hsCRP were determined by turbidimetry. Tumour necrosis factor (TNF)-α, interleukin (IL)-6, IL-10, IL-1β, and soluble (s) E-selectin were assessed by Multiplex assay. Additionally, mCRP forms were determined in the serum of AP patients with a baseline moderate to high cardiovascular risk based on hsCRP stratification (hsCRP ≥1mg/L) by immunowestern blot (n=15). Also, CRP isoforms were explored in ALEOs from AP individuals (n=4). Data were analysed with StataV16. Results: Periapical index and ALEO sizes were reduced at both follow-up visits after RCT (p<.05). Serum levels of TNF-α, IL-6, IL-10, IL-1β, and sE-selectin did not show significant differences. CRP was borderline reduced at 1month (p=.04); however, in AP individuals at cardiovascular risk (hsCRP≥1mg/L), hsCRP and its monomeric isoform significantly decreased at 1 and 6months (p<.05). Conclusions: High-sensitivity CRP and mCRP are reduced after RCT in AP indi viduals at cardiovascular risk.	en
dc.description.version	version_publicada
dc.format	application/pdf
dc.identifier.citation	International Endodontic Journal (2024) p. 1–10.
dc.identifier.doi	10.1111/iej.14029
dc.identifier.issn	0143-2885
dc.identifier.issne	1365-2591
dc.identifier.orcid	https://orcid.org/0000-0002-8554-7181
dc.identifier.uri	https://hdl.handle.net/20.500.12254/3607
dc.language.iso	eng
dc.publisher	John Wiley & Sons.
dc.rights	Acceso abierto
dc.rights.accessRights	http://purl.org/coar/access_right/c_abf2
dc.rights.license	Atribución 4.0 Internacional (CC BY 4.0)
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject	Cardiovascular Diseases; C-Reactive Protein; Heart Disease Risk Factor; Periapical Periodontitis; Inflammatory Markers; Systemic Inflammation; Root Canal Treatment; Apical Periodontitis; Clinical Evaluation; Prospective Study
dc.subject.ods	ODS 3-Salud/Bienestar
dc.subject.oecd	13-Trabajo; 15-Biología/Salud
dc.title	Reduced C-reactive protein levels after root canal treatment in clinically healthy young apical periodontitis individuals at cardiovascular risk. A prospective study	en
dc.type	Article
dc.type.coar	http://purl.org/coar/resource_type/c_6501
dcterms.accessRights	El artículo completo no puede ser publicado en el Repositorio Institucional debido a los permisos de copyright definidos por la editorial publicadora. Ingrese a través del DOI.