Baseline body fat percentage is associated to weight and fat mass gain from high-fat overfeeding over 8 weeks

Vista sencilla de ítem
dc.contributor.authorGalgani, Jose E.
dc.contributor.authorFernández-Verdejo, Rodrigo
dc.contributor.authorBray, George A.
dc.contributor.authorSmith, Steven R.
dc.contributor.authorGhosh, Sujoy
dc.contributor.authorJavvadi, Pravalika
dc.contributor.authorRavussin, Eric
dc.date.accessioned2025-07-10T19:59:15Z
dc.date.available2025-07-10T19:59:15Z
dc.date.issued2025-04-21
dc.description.abstractBackground & aims: Epidemiological data suggest that participants with lower vs. higher body mass index (BMI) resist exposure to the obesogenic environment. To test this, we analyzed the relationship between overfeeding-induced weight and fat mass gains with baseline BMI and body fat percentage. Methods: In this controlled intervention study, 34 men (age: 26±5 y old; BMI: 25.5±2.4 kg/m2, body fat [DXA]: 19.3±5.1%) consumed for 8 weeks 40% more energy than needed at weight maintenance. The energy costs of weight and fat mass gain were calculated as the 8-week excess energy consumed divided by weight or fat mass gain. Energy expenditure (baseline and after overfeeding) was determined using a metabolic chamber and doubly labeled water. Transcriptomic analysis was conducted from abdominal subcutaneous adipose tissue samples. Results: Body weight increased 7.2±2.1 kg and fat mass 4.0±1.4 kg. There was no statistical association between baseline BMI and weight and fat mass gains. However, baseline body fat percentage was significantly associated with weight (r=0.57) and fat mass (r=0.59) gains. Body fat percentage was also statistically associated with energy cost of weight (r=-0.38) and fat mass (r=-0.40) gains. Metabolic adaptation in energy expenditure (adaptive thermogenesis) was unrelated to the energy cost of weight and fat mass gains. Transcriptomics analysis showed that high energy cost of weight gain was associated with up-regulation of inflammation-related pathways. Conclusion: Body fat percentage at baseline was inversely associated with overfeeding-induced weight and fat gain resistance. The underlying compensatory response appears unrelated to changes in energy expenditure.
dc.identifier.citationThe Journal of Clinical Endocrinology & Metabolism, (2025) p 1-11.
dc.identifier.doihttps://doi.org/10.1210/clinem/dgaf247
dc.identifier.issn0021-972X
dc.identifier.issne1945-7197
dc.identifier.orcidhttps://orcid.org/0000-0002-5948-2281
dc.identifier.urihttps://hdl.handle.net/20.500.12254/4194
dc.language.isoen
dc.publisherOxford University Press; Endocrine Society
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectAdaptive thermogenesis
dc.subjectAdipose tissue function
dc.subjectFatness
dc.subjectObesity
dc.subjectWeight gain
dc.titleBaseline body fat percentage is associated to weight and fat mass gain from high-fat overfeeding over 8 weeks
dc.typeArticle
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Galgani et al.pdf
Tamaño:
154.48 KB
Formato:
Adobe Portable Document Format
Descripción:
Texto referencial
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
347 B
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Artículos de Revistas