Therapeutic antisense oligonucleotides in oncology: from bench to bedside
Fecha
2024-08-23
Profe guía
Perfil ORCID
Título de la revista
ISSN de la revista
Título del volumen
Editor
MDPI
ISBN
ISSN
ISSNe
2072-6694
Resumen
Advancements in our comprehension of tumor biology and chemoresistance have spurred the development of treatments that precisely target specific molecules within the body. Despite the expanding landscape of therapeutic options, there persists a demand for innovative approaches to address unmet clinical needs. RNA therapeutics have emerged as a promising frontier in this realm, offering novel avenues for intervention such as RNA interference and the utilization of antisense oligonucleotides (ASOs). ASOs represent a versatile class of therapeutics capable of selectively targeting messenger RNAs (mRNAs) and silencing disease-associated proteins, thereby disrupting pathogenic processes at the molecular level. Recent advancements in chemical modification and carrier molecule design have significantly enhanced the stability, biodistribution, and intracellular uptake of ASOs, thereby bolstering their therapeutic potential. While ASO therapy holds promise across various disease domains, including oncology, coronary angioplasty, neurological disorders, viral, and parasitic diseases, our review manuscript focuses specifically on the application of ASOs in targeted cancer therapies. Through a comprehensive examination of the latest research findings and clinical developments, we delve into the intricacies of ASO-based approaches to cancer treatment, shedding light on their mechanisms of action, therapeutic efficacy, and prospects.
Descripción
Lugar de Publicación
Sponsorship
Citación
Cancers, Vol. 16, N°17, 2940 (2024) p. 1-35.
Palabras clave
Antisense oligonucleotides, Non-coding RNA, Antisense oligonucleotide delivery system, Cancer therapy, Grb2.
Licencia
Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)