Health screening of middle-aged women: what factors impact longevity?

Blumel, Juan E.; Aedo, Sócrates; Murray, Nigel P.; Vallejo, María S.

Health screening of middle-aged women: what factors impact longevity?

dc.contributor.author	Blumel, Juan E.
dc.contributor.author	Aedo, Sócrates
dc.contributor.author	Murray, Nigel P.
dc.contributor.author	Vallejo, María S.
dc.date.accessioned	2024-11-29T18:18:39Z
dc.date.available	2024-11-29T18:18:39Z
dc.date.issued	2022-08
dc.description.abstract	Objective The aim of this study was to measure the impact of different risk factors in middle-aged women on longevity evaluated after three decades of an initial health screening. Methods Women who received an annual check-up between 1990 and 1993 were recruited. Anamnesis and physical examination were recorded. Blood samples for the measurement of glycemia and lipids were taken. Data are reported as of December 2021. Results A total of 1,158 women aged 40 to 60 were studied. At 30.9 years of follow-up, the Kaplan-Meier overall survival was 75.6% (95% confidence interval, 72.6-78.3). The main causes of the 260 deaths observed were the following: cancer (n = 88; 33.8%), cardiovascular disease (n = 55; 21.2%), and infectious disease (n = 41; 15.8%). The following hazard ratios were found with the flexible parametric survival model: personal history of fracture (hazard ratio, 2.55; 95% confidence interval, 1.29-5.02; P = 0.007), type 2 diabetes mellitus (2.14; 1.18-3.88; P = 0.012), personal history of heart disease (1.85; 1.09-3.13; P = 0.022), chronic arterial hypertension (1.65; 1.25-2.17; P < 0.001), postmenopausal status (1.60; 1.13-2.26; P = 0.008), unskilled jobs (1.56; 1.17-2.07; P = 0.002), cigarette smoking (1.51; 1.17-1.94; P = 0.002), age (1.06; 1.03-1.09; P < 0.001), body mass index (1.04; 1.01-1.07; P = 0.004), multiparous (0.72; 0.56-0.93; P = 0.012), and active sexual intercourse (0.68; 0.52-0.87; P = 0.003). Lipid disorders did not reach statistical significance as a risk factor. Conclusions In this cohort, it was observed that most of the classic risk factors for mortality were present. However, a history of fracture appears in middle-aged women as a strong predictor of mortality, surpassing diabetes and arterial hypertension. Multiparity, on the other hand, was a protective factor.
dc.identifier.citation	Menopause, Vol. 29, N°9 (2022) p. 1008-1013
dc.identifier.doi	https://doi.org/10.1097/GME.0000000000002025
dc.identifier.issne	1530-0374
dc.identifier.orcid	https://orcid.org/0000-0001-5567-3374
dc.identifier.orcid	https://orcid.org/0000-0001-8154-8550
dc.identifier.uri	http://hdl.handle.net/20.500.12254/3950
dc.language.iso	en	es
dc.publisher	The North American Menopause Society
dc.rights	Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subject	Cohort
dc.subject	Health screening
dc.subject	Middle-aged women
dc.subject	Mortality
dc.subject	Risk factors
dc.subject.other	menopause, risk factors, long-livity	es
dc.title	Health screening of middle-aged women: what factors impact longevity?	es
dc.type	Article