Uncovering the muscle clock–mitochondria axis through exercise

• Castro-Sepúlveda, Mauricio

• Molecular Clock

Emerging evidence suggests an interplay between the molecular clock and mitochondrial dynamics in skeletal muscle. In this Forum article, we hypothesize that exercise, as a metabolic challenge, provides a powerful physiological model to investigate the clock–mitochondria axis and its regulatory role in muscle function and metabolic health in humans.