Feasibility of using ultrasound for drug delivery through micellar systems

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dc.contributor.authorMarambio, E.
dc.contributor.authorVelásquez, P.
dc.contributor.authorCepeda-Plaza, M.
dc.contributor.authorGalleguillos Silva, Renato Bruno
dc.date.accessioned2025-07-17T16:47:40Z
dc.date.available2025-07-17T16:47:40Z
dc.date.issued2025-04-02
dc.description.abstractA study of micellar structures subjected to continuous high-intensity ultrasonic perturbation was carried out. The micelles were characterized by high-speed absorption spectrophotometry and the use of fluorophores, such as Rhodamine 123, as a spectroscopic indicator of the micellar kinetic process. It was found that above the critical micellar concentration, the absorbance peak of the fluorophore experiences a 14 nm red shift. Preliminary experiments indicate a reversal of this shift under certain ultrasonic conditions. In subsequent experiments, no effect of high intensity ultrasonic radiation on the micellar systems studied was observed. A dependence of the spectroscopic response of Rh123 on temperature is found, which can be confused with the effect of micelle breaking in solutions. The study presented considers the use of Quillaja Saponaria Molina and Triton X-100 as a surfactant, but it is extensible to other micellar systems.
dc.identifier.citation2024 IEEE 17th International Conference on Nano/Molecular Medicine & Engineering (NANOMED), Honolulu, HI, USA, (2024) pp. 108-112.
dc.identifier.doihttps://doi.org/10.1109/NANOMED64244.2024.10946060
dc.identifier.issn2836-0249
dc.identifier.issne2836-0257
dc.identifier.orcidhttps://orcid.org/0000-0001-6065-5218
dc.identifier.urihttps://hdl.handle.net/20.500.12254/4225
dc.language.isoen
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectDrug delivery
dc.subjectUltrasonic disruption
dc.subjectmicellar systems
dc.subjectQuillaja Saponaria
dc.titleFeasibility of using ultrasound for drug delivery through micellar systems
dc.typeArticle
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