Pharmacological Research Agenda on Adult Extracorporeal Membrane Oxygenation Using the Delphi Method: A Position Article of the Extracorporeal Membrane Oxygenation Pharmacology Network

Vista sencilla de ítem
dc.contributor.authorFerre Contreras, Andrés
dc.contributor.authorMorales Castro, Diana
dc.contributor.authorAl-Fares, Abdulrahman Abdullah
dc.contributor.authorPaternoster, Gianluca
dc.contributor.authorLyster, Haifa
dc.contributor.authorHohlfelder, Benjamin
dc.contributor.authorArias Ortiz, Julian
dc.contributor.authorAbdul-Aziz, Mohd Hafiz
dc.contributor.authorHerr, Daniel
dc.contributor.authorAlraish, Rawan
dc.contributor.authorPalavecino, Marcela
dc.contributor.authorMilella, Luigi
dc.contributor.authorWatt, Kevin
dc.contributor.authorAlkazemi, Afrah
dc.contributor.authorCarini, Federico Carlos
dc.contributor.authorRoberts, Jason A.
dc.contributor.authorRiera del Brio, Jordi
dc.contributor.authorPau Parra, Alba
dc.contributor.authorKakar, Vivek
dc.contributor.authorDureau, Pauline
dc.contributor.authorDuceppe, Marc-Alexandre
dc.contributor.authorAlm, Mark
dc.contributor.authorCha, Stephanie
dc.contributor.authorShekar, Kiran
dc.contributor.authorDzierba, Amy L.
dc.date.accessioned2025-08-25T15:49:18Z
dc.date.available2025-08-25T15:49:18Z
dc.date.issued2025-08-11
dc.description.abstractObjectives: Extracorporeal membrane oxygenation (ECMO) is a critical intervention for patients with severe cardiac or respiratory failure. However, pharmacological management for ECMO-supported patients presents unique challenges due to alterations in drug pharmacokinetics and pharmacodynamics induced by the ECMO circuit and underlying critical illness. This position paper identifies key research priorities in ECMO pharmacology using a structured Delphi consensus process and provides a focused review of current evidence and knowledge gaps to inform future research and clinical practice. Data sources: An international panel of 25 ECMO pharmacology experts from 13 countries representing the ECMO Pharmacology Network contributed to this position article. Literature was reviewed to summarize current evidence and identify knowledge gaps in ECMO pharmacology. Study selection: The Delphi process involved iterative, anonymous voting by the expert panel to propose key research priorities. Items selected were based on their perceived importance to improving clinical outcomes and advancing pharmacological management in ECMO-supported patients. Data extraction: Key research priorities were identified, and a detailed literature review was conducted for each, focusing on pharmacokinetics/pharmacodynamics, related therapeutic challenges, and knowledge gaps. Future research directions were outlined. Data synthesis: Six critical ECMO pharmacotherapy research priorities were identified: 1) pharmacokinetics/pharmacodynamics reporting, 2) interactions between ECMO and renal replacement therapy, 3) antimicrobial dosing, 4) analgesia and sedation for pain and agitation, 5) sedation and neuromuscular blocking agents for increased work of breathing, and 6) anticoagulation. The review for the key research priorities highlighted substantial gaps in the existing literature, emphasizing the need for comprehensive studies addressing these issues to enhance pharmacotherapy in ECMO patients, improve clinical outcomes, and contribute to the development of evidence-based guidelines for this complex population. Conclusions: ECMO presents unique challenges to drug pharmacokinetics and pharmacodynamics, complicating pharmacotherapy in critically ill patients. Further research addressing identified gaps is essential to develop evidence-based treatment strategies and enhance patient outcomes.
dc.identifier.citationCritical Care Medicine, Vol, 53 (2025) p. 1-15.
dc.identifier.doihttps://doi.org/10.1097/CCM.0000000000006806
dc.identifier.issne1530-0293
dc.identifier.orcidhttps://orcid.org/0000-0003-1770-244X
dc.identifier.urihttps://hdl.handle.net/20.500.12254/4275
dc.language.isoen
dc.publisherSociety of Critical Care Medicine and Wolters Kluwer Health
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectExtracorporeal membrane oxygenation
dc.subjectPharmacodynamics
dc.subjectPharmacokinetics
dc.subjectPosition paper
dc.titlePharmacological Research Agenda on Adult Extracorporeal Membrane Oxygenation Using the Delphi Method: A Position Article of the Extracorporeal Membrane Oxygenation Pharmacology Network
dc.typeArticle
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
pharmacological_research_agenda_on_adult.pdf Andrés Ferré-1.pdf
Tamaño:
174.58 KB
Formato:
Adobe Portable Document Format
Descripción:
Texto referencial
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
347 B
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Artículos de Revistas