Phlorotannins: novel orally administrated bioactive compounds that induce mitochondrial dysfunction and oxidative stress in cancer

Simón, Layla; Arazo-Rusindo, Migdalia; Quest, Andrew F. G.; Mariotti-Celis, María Salomé

Phlorotannins: novel orally administrated bioactive compounds that induce mitochondrial dysfunction and oxidative stress in cancer

dc.contributor.author	Simón, Layla
dc.contributor.author	Arazo-Rusindo, Migdalia
dc.contributor.author	Quest, Andrew F. G.
dc.contributor.author	Mariotti-Celis, María Salomé
dc.date.accessioned	2024-11-26T14:02:50Z
dc.date.available	2024-11-26T14:02:50Z
dc.date.issued	2023-09-07
dc.description.abstract	Mitochondrial dysfunction is an interesting therapeutic target to help reduce cancer deaths, and the use of bioactive compounds has emerged as a novel and safe approach to solve this problem. Here, we discuss the information available related to phlorotannins, a type of polyphenol present in brown seaweeds that reportedly functions as antioxidants/pro-oxidants and anti-inflammatory and anti-tumorigenic agents. Specifically, available evidence indicates that dieckol and phloroglucinol promote mitochondrial membrane depolarization and mitochondria-dependent apoptosis. Phlorotannins also reduce pro-tumorigenic, -inflammatory, and -angiogenic signaling mechanisms involving RAS/MAPK/ERK, PI3K/Akt/mTOR, NF-κB, and VEGF. In doing so, they inhibit pathways that favor cancer development and progression. Unfortunately, these compounds are rather labile and, therefore, this review also summarizes approaches permitting the encapsulation of bioactive compounds, like phlorotannins, and their subsequent oral administration as novel and non-invasive therapeutic alternatives for cancer treatment.
dc.identifier.citation	Antioxidants, Vol. 12, N°9, 1734 (2023) p. 1-18.
dc.identifier.doi	https://doi.org/10.3390/antiox12091734
dc.identifier.issn	2076-3921
dc.identifier.orcid	https://orcid.org/0000-0002-0130-3519
dc.identifier.orcid	https://orcid.org/0000-0003-1357-812X
dc.identifier.uri	http://hdl.handle.net/20.500.12254/3911
dc.language.iso	en
dc.publisher	MDPI
dc.rights	Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subject	Metabolism
dc.subject	Antioxidants
dc.subject	Pro-oxidants
dc.subject	Phloroglucinol
dc.subject	Encapsulation
dc.title	Phlorotannins: novel orally administrated bioactive compounds that induce mitochondrial dysfunction and oxidative stress in cancer
dc.type	Article