Treatment of multisystem inflammatory syndrome in children.

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dc.contributor.authorMcArdle, A.J.
dc.contributor.authorVito, O.
dc.contributor.authorPate, H.
dc.contributor.authorSeaby, E.G.
dc.contributor.authorShah, P.
dc.contributor.authorWilson, C.
dc.contributor.authorBroderick, C.
dc.contributor.authorNijman, R.
dc.contributor.authorTremoulet, A.H.
dc.contributor.authorMunblit, D.
dc.contributor.authorUlloa‑Gutierrez, R.
dc.contributor.authorM.J. Carter
dc.contributor.authorHoggart, T. De, C.
dc.contributor.authorWhittaker, E.
dc.contributor.authorHerberg, J.A.
dc.contributor.authorKaforou, M.
dc.contributor.authorCunnington, A.J.
dc.contributor.authorLevin, M.
dc.contributor.authorDíaz, F. (The Best Available Treatment Study (BATS) Consortium )
dc.date.accessioned2021-12-17T15:02:09Z
dc.date.available2021-12-17T15:02:09Z
dc.date.issued2021-07-01
dc.descriptionPublicación Multicéntrica. Universidad Finis Terrae listada como colaboradora por participación del autor Este trabajo quedará a disposición en Enero 2022es
dc.description.abstractBackground Evidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2. METHODS We performed an international observational cohort study of clinical and outcome data regarding suspected MIS-C that had been uploaded by physicians onto a Web-based database. We used inverse probability weighting and generalized linear models to evaluate intravenous immune globulin (IVIG) as a reference, as compared with IVIG plus glucocorticoids and glucocorticoids alone. There were two primary outcomes: the first was a composite of inotropic support or mechanical ventilation by day 2 or later or death; the second was a reduction in disease severity on an ordinal scale by day 2. Secondary outcomes included treatment escalation and the time until a reduction in organ failure and inflammation. RESULTS Data were available regarding the course of treatment for 614 children from 32 countries from June 2020 through February 2021; 490 met the World Health Organization criteria for MIS-C. Of the 614 children with suspected MIS-C, 246 received primary treatment with IVIG alone, 208 with IVIG plus glucocorticoids, and 99 with glucocorticoids alone; 22 children received other treatment combinations, including biologic agents, and 39 received no immunomodulatory therapy. Receipt of inotropic or ventilatory support or death occurred in 56 patients who received IVIG plus glucocorticoids (adjusted odds ratio for the comparison with IVIG alone, 0.77; 95% confidence interval [CI], 0.33 to 1.82) and in 17 patients who received glucocorticoids alone (adjusted odds ratio, 0.54; 95% CI, 0.22 to 1.33). The ad- adjusted odds ratios for a reduction in disease severity were similar in the two groups, as compared with IVIG alone (0.90 for IVIG plus glucocorticoids and 0.93 for glucocorticoids alone). The time until a reduction in disease severity was similar in the three groups. CONCLUSIONS We found no evidence that recovery from MIS-C differed after primary treatment with IVIG alone, IVIG plus glucocorticoids, or glucocorticoids alone, although significant differences may emerge as more data accrue. (Funded by the European Union’s Horizon 2020 Program and others; BATS ISRCTN number, ISRCTN69546370.)es
dc.description.sponsorshipBATS Consortium. Best Available Treatment Study, International Cohortes
dc.identifier.citationN Engl J Med 2021 Jul 1;385(1):11-22.es
dc.identifier.issn1533-4406
dc.identifier.orcid0000-0003-4763-074Xes
dc.identifier.orcidDOI: 10.1056/NEJMoa2102968
dc.identifier.urihttps://hdl.handle.net/20.500.12254/2160
dc.language.isoenes
dc.publisherMassachusetts Medical Societyes
dc.relation.ispartofseriesNew England Journal of Medicine;Vol.385, N.1
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subject.otherMIS-Ces
dc.subject.otherCOVID-19es
dc.subject.otherpediatricses
dc.subject.othershockes
dc.titleTreatment of multisystem inflammatory syndrome in children.es
dc.typeArtículoes
dcterms.accessRightsEl artículo completo no puede ser publicado en el Repositorio Institucional debido a los permisos de copyright definidos por la editorial publicadora
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