The role of cellular senescence in endothelial dysfunction and vascular remodelling in arteriovenous fistula maturation

Vista sencilla de ítem
dc.contributor.authorGonzález, Ignacia
dc.contributor.authorMaldonado-Agurto, Rodrigo
dc.date.accessioned2025-06-17T20:16:43Z
dc.date.available2025-06-17T20:16:43Z
dc.date.issued2025-02-20
dc.description.abstractHaemodialysis (HD) is often required for patients with end-stage renal disease. Arteriovenous fistulas (AVFs), a surgical procedure connecting an artery to a vein, are the preferred vascular access for HD due to their durability and lower complication rates. The aim of AVFs is to promote vein remodelling to accommodate increased blood flow needed for dialysis. However, many AVFs fail to mature properly, making them unsuitable for dialysis. Successful maturation requires remodelling, resulting in an increased luminal diameter and thickened walls to support the increased blood flow. After AVF creation, haemodynamic changes due to increased blood flow on the venous side of the AVF initiate a cascade of events that, when successful, lead to the proper maturation of the AVF, making it suitable for cannulation. In this process, endothelial cells play a crucial role since they are in direct contact with the frictional forces exerted by the blood, known as shear stress. Patients requiring HD often have other conditions that increase the burden of senescent cells, such as ageing, diabetes and hypertension. These senescent cells are characterized by irreversible growth arrest and the secretion of pro-inflammatory and pro-thrombotic factors, collectively known as the senescence-associated secretory phenotype (SASP). This accumulation can impair vascular function by promoting inflammation, reducing vasodilatation, and increasing thrombosis risk, thus hindering proper AVF maturation and function. This review explores the contribution of senescent endothelial cells to AVF maturation and explores potential therapeutic strategies to alleviate the effects of senescent cell accumulation, aiming to improve AVF maturation rates.
dc.identifier.citationThe Psysiological Society (2025) p. 1-20.
dc.identifier.doihttps://doi.org/10.1113/JP287387
dc.identifier.issn0022-3751
dc.identifier.issne1469-7793
dc.identifier.orcidhttps://orcid.org/0000-0002-8326-9800
dc.identifier.urihttps://hdl.handle.net/20.500.12254/4150
dc.language.isoen
dc.publisherWiley
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectArteriovenous fistulas
dc.subjectEndothelial dysfunction
dc.subjectEndothelial senescence
dc.subjectShear stress
dc.subjectVascular remodelling
dc.titleThe role of cellular senescence in endothelial dysfunction and vascular remodelling in arteriovenous fistula maturation
dc.typeArticle
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
The Journal of Physiology - 2025 - González - The role of cellular senescence in endothelial dysfunction and vascular (1).pdf
Tamaño:
1.22 MB
Formato:
Adobe Portable Document Format
Descripción:
Texto completo
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
347 B
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Artículos de Revistas