A stable nanosilver decorated phosphorene nanozyme with phosphorus- doped porous carbon microsphere for intelligent sensing of 8-hydroxy-20- deoxyguanosine

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dc.contributor.authorSheng, Yingying
dc.contributor.authorYifu Zhu
dc.contributor.authorCerón, María Luisa
dc.contributor.authorYufu Yi
dc.contributor.authorPeng Liu
dc.contributor.authorPeng Wang
dc.contributor.authorTing Xue
dc.contributor.authorCamarada, María Belén
dc.contributor.authorYangping Wen
dc.date.accessioned2021-12-21T12:56:08Z
dc.date.available2021-12-21T12:56:08Z
dc.date.issued2021-08
dc.description.abstractNanozyme based on the silver nanoparticles (AgNPs) decorated highly water-oxygen stable phosphorene (BP) nanohybrid with phosphorus-doped porous carbon microspheres (P-PCMs) is applied as an intelligent sensing platform for the electrochemical detection of 8-hydroxy-2′-deoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage in human urine sample. The density functional theory (DFT) is use for investigating the effect of silver on the conductivity level of BP and discussing a possible mechanism for the electrocatalytic oxidation of 8-OHdG. The Ag+ is in-situ reduced as AgNPs that grows onto the BP surface for the controllable preparation of BP-AgNPs with effective surface passivation among different metal ions decorated BP. P-PCMs with 4.9-fold enhancement in specific surface area (1636.73 m2 g−1) are prepared by hydrothermal carbonization of α-cyclodextrin as carbon sources, then calcinate in the presence of phosphoric acid as an activator and dopant. P-PCMs-BP-AgNPs are prepared by the ultrasound-assisted liquid-phase exfoliation with the addition of Ag+, and both P-PCMs and black phosphorus crystals are sufficiently grinded. The P-PCMs-BP-AgNPs nanohybrid displays good long-term water-oxygen stability, extraordinary specific surface area, superior electrocatalytic capacity with 303-fold enhancement, enzyme-like characteristics with Imax of 100 μA and Km of 29 μM. The machine learning (ML) model with artificial neural network (ANN) algorithm is employed for the intelligent output of 8-OHdG in real sample with acceptable recovery in work range from 0.2 to 125 μM.es
dc.identifier.issn1572-6657
dc.identifier.orcid0000-0001-8662-8189es
dc.identifier.orcidhttps://doi.org/10.1016/j.jelechem.2021.115522
dc.identifier.urihttps://hdl.handle.net/20.500.12254/2171
dc.language.isoenes
dc.publisherElsevieres
dc.relation.ispartofseriesJournal of Electroanalytical Chemistry;895
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectNanomaterialeses
dc.subject.otherPhosphorenees
dc.subject.otherPorous carbones
dc.subject.otherNanozymees
dc.subject.otherMachine learninges
dc.subject.otherElectrochemical sensores
dc.subject.otherWater-oxygen stabilityes
dc.titleA stable nanosilver decorated phosphorene nanozyme with phosphorus- doped porous carbon microsphere for intelligent sensing of 8-hydroxy-20- deoxyguanosinees
dc.typeArtículoes
dcterms.accessRightsEl artículo completo no puede ser publicado en el Repositorio Institucional debido a los permisos de copyright definidos por la editorial publicadora
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