Factores asociados a ventilación mecánica prolongada en niños con fallo respiratorio de causa pulmonar: estudio de cohortes del registro de LARed Network

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dc.contributor.authorBarajas-Romero, Juan Sebastían
dc.contributor.authorVásquez-Hoyos, Pablo
dc.contributor.authorPardo, Rosalba
dc.contributor.authorJaramillo-Bustamante, Juan Camilo
dc.contributor.authorGrigolli, Regina
dc.contributor.authorMonteverde-Fernández, Nicolas
dc.contributor.authorGonzalez-Dambrauskas, Sebastián
dc.contributor.authorJabornisky, Roberto
dc.contributor.authorCruces, Pablo
dc.contributor.authorWegner, Adriana
dc.contributor.authorDíaz, Franco
dc.contributor.authorPietroboni, Pietro
dc.date.accessioned2024-02-01T13:44:09Z
dc.date.available2024-02-01T13:44:09Z
dc.date.issued2023-06-15
dc.description.abstractObjectives: To identify factors associated with prolonged mechanical ventilation (pMV) in pediatric patients in pediatric intensive care units (PICUs). Design: Secondary analysis of a prospective cohort. Setting: PICUs in centers that are part of the LARed Network between April 2017 and January 2022. Participants: Pediatric patients on mechanical ventilation (IMV) due to respiratory causes. We defined IMV time greater than the 75th percentile of the global cohort. Main variables of interest: Demographic data, diagnoses, severity scores, therapies, complications, length of stay, morbidity, and mortality. Results: 1698 children with MV of 8±7 days were included, and pIMV was defined as 9 days. Factors related to admission were age under 6 months (OR 1.61, 95% CI 1.17-2.22), bronchopulmonary dysplasia (OR 3.71, 95% CI 1.87-7.36), and fungal infections (OR 6.66, 95% CI 1.87-23.74), while patients with asthma had a lower risk of pIMV (OR 0.30, 95% CI 0.12-0.78). Regarding evolution and length of stay in the PICU, it was related to ventilation-associated pneumonia (OR 4.27, 95% CI 1.79-10.20), need for tracheostomy (OR 2.91, 95% CI 1.89-4.48), transfusions (OR 2.94, 95% CI 2.18-3.96), neuromuscular blockade (OR 2.08, 95% CI 1.48-2.93), high-frequency ventilation (OR 2.91, 95% CI 1.89-4.48), and longer PICU stay (OR 1.13, 95% CI 1.10-1.16). In addition, mean airway pressure greater than 13cmH2O was associated with pIMV (OR 1.57, 95% CI 1.12-2.21). Conclusions: Factors related to IMV duration greater than 9 days in pediatric patients in PICUs were identified in terms of admission, evolution, and length of stay
dc.identifier.citationMedicina Intensiva, Vol. 48 (2024) p. 23-36
dc.identifier.doihttps://doi.org/10.1016/j.medine.2023.07.001
dc.identifier.issn2173-5727
dc.identifier.orcidhttps://orcid.org/0000-0003-4763-074X
dc.identifier.urihttp://hdl.handle.net/20.500.12254/3598
dc.language.isoen
dc.publisherElsevier
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectPediatricses
dc.subjectPARDSes
dc.subjectMechanical ventilationen
dc.subjectSíndrome de dificultad respiratoriaen
dc.subject.otherpediatricses
dc.subject.otherPARDSes
dc.subject.otherMechanical Ventilationes
dc.titleFactores asociados a ventilación mecánica prolongada en niños con fallo respiratorio de causa pulmonar: estudio de cohortes del registro de LARed Networkes
dc.title.alternativeFactors associated with prolonged mechanical ventilation in children with pulmonary failure: Cohort study from the LARed Network registry.en
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