Boron Schiff bases derived from a-amino acids as nucleoli/cytoplasm cell-staining fluorescent probes in vitro

Lara-Cerón, Jesús A.; Jiménez Pérez, Víctor M.; Xochicale-Santana, Leonardo; Ochoa, María E.; Chávez-Reyes, Arturo; Muñoz-Flores, Blanca M.

Boron Schiff bases derived from a-amino acids as nucleoli/cytoplasm cell-staining fluorescent probes in vitro

dc.contributor.author	Lara-Cerón, Jesús A.	es
dc.contributor.author	Jiménez Pérez, Víctor M.	es
dc.contributor.author	Xochicale-Santana, Leonardo	es
dc.contributor.author	Ochoa, María E.	es
dc.contributor.author	Chávez-Reyes, Arturo	es
dc.contributor.author	Muñoz-Flores, Blanca M.	es
dc.date.accessioned	2023-05-18T15:49:07Z
dc.date.available	2023-05-18T15:49:07Z
dc.date.issued	2020-08-26
dc.description.abstract	The size, shape, and number of nucleoli in a cell's nucleus might help to distinguish a malignant from a benign tumor. Cellular biology and histopathology often require better visualization to understand nucleoli-related processes, thus organelle-specific fluorescent markers are needed. Here, we report the design, synthesis, and fully chemo-photophysical characterization of fluorescent boron Schiff bases (BOSCHIBAs), derived from a-amino acids (i.e., phenylalanine, tyrosine and tryptophan), with nucleoli- and cytoplasm-specific staining in cells. It is the first time that Boron Schiff bases derived from a-amino acids act as notorious dual (nucleoli and cytoplasm) cell-staining fluorescent probes. The boron derivatives not only showed good photostability and acceptable quantum yields ($5%) in solution, but also exhibited low cytotoxicity (>90% cell viability at 0.1 and 1 mg mL 1), which make them good candidates to be used in medical diagnosis.	en_US
dc.identifier.citation	RSC Advances, Vol. 10, N° 53 (2020) p. 31748-31757	en_US
dc.identifier.doi	https://doi.org/10.1039/D0RA05948J
dc.identifier.issn	2046-2069	en_US
dc.identifier.orcid	https://orcid.org/0000-0002-6655-815X
dc.identifier.uri	http://hdl.handle.net/20.500.12254/3255	en_US
dc.language.iso	en	en_US
dc.publisher	The Royal Society of Chemistry	en_US
dc.rights	Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subject.other	Boron Schiff bases	en_US
dc.subject.other	A-amino acids	en_US
dc.subject.other	Cell-staining	en_US
dc.subject.other	Fluorescent probes	en_US
dc.title	Boron Schiff bases derived from a-amino acids as nucleoli/cytoplasm cell-staining fluorescent probes in vitro	en_US
dc.type	Artículo	es