A Systematic Review and Meta-Analysis on the Prevalence of Variants in the Pancreaticobiliary Duct Junction and Its Association with Cancer

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dc.contributor.authorValenzuela Fuenzalida, Juan José
dc.contributor.authorBeas-Gambi, Antonia
dc.contributor.authorMatta-Leiva, Josefa
dc.contributor.authorMartínez-Hernández, Daniela
dc.contributor.authorMilos, Daniel
dc.contributor.authorOrellana-Donoso, Mathias
dc.contributor.authorSuazo Santibañez, Alejandra
dc.contributor.authorBruna-Mejías, Alejandro
dc.contributor.authorSebastian Riveros, Andres
dc.contributor.authorBecerra-Farfán, Alvaro
dc.contributor.authorSanchis-Gimeno, Juan
dc.contributor.authorGutierrez-Espinoza, Héctor
dc.contributor.authorBastidas-Caldes, Carlos
dc.date.accessioned2025-09-29T14:49:16Z
dc.date.available2025-09-29T14:49:16Z
dc.date.issued2025-04-25
dc.description.abstractThe objective of this study was to describe the anatomical variants of the pancreaticobiliary junction and how its position or structural change could be associated with hepatic, duodenal, and pancreatic clinical complications. Methods: We searched MEDLINE, Scopus, Web of Science (WOS), Google Scholar, CINAHL, and EMBASE databases from their inception up to September 2024. Results: Two authors independently performed the search, study selection, data extraction, and assessed the methodological quality with an assurance tool for anatomical studies (AQUA). Finally, the pooled prevalence was estimated using a random effects model. A total of 59 studies with a total of 22,752 participants were included in this review. The overall prevalence of the anomalous pancreaticobiliary junction (APBJ) variant was 12% (95% CI = 6% to 18%). The prevalence of cancer associated with variants of APBJ was 29% (95% CI = 23% to 34%). Conclusions: In the present anatomical systematic review and meta-analysis, we found that a longer common channel correlated with a higher prevalence of bile duct or gallbladder malignancy, due to the backward flow of bile which occurs as a result of the position and distance of the bile ducts, as well as pancreatic failing. Hence, APBJs are of great interest for gastroduodenal surgeons.
dc.identifier.citationBiomedicines, Vol. 13, N°5, 1039 (2025) p. 1-21.
dc.identifier.doihttps://doi.org/10.3390/biomedicines13051039
dc.identifier.issn2227-9059
dc.identifier.orcidhttps://orcid.org/0000-0002-1781-062X
dc.identifier.urihttps://hdl.handle.net/20.500.12254/4319
dc.language.isoen
dc.publisherMDPI
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectPancreaticobiliary junction (PBJ)
dc.subjectPancreaticobiliary maljunction
dc.subjectCancer
dc.subjectPancreaticobiliary junction cancer
dc.titleA Systematic Review and Meta-Analysis on the Prevalence of Variants in the Pancreaticobiliary Duct Junction and Its Association with Cancer
dc.typeArticle
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