Neurocognitive correlates of semantic memory navigation in Parkinson’s disease

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dc.contributor.authorToro-Hernández, Felipe Diego
dc.contributor.authorMigeot, Joaquín
dc.contributor.authorMarchant, Nicolás
dc.contributor.authorOlivares, Daniela
dc.contributor.authorFerrante, Franco
dc.contributor.authorGonzález-Gómez, Raúl
dc.contributor.authorGonzález Campo, Cecilia
dc.contributor.authorFittipaldi, Sol
dc.contributor.authorRojas-Costa, Gonzalo M
dc.contributor.authorMoguilner, Sebastian
dc.contributor.authorSlachevsky, Andrea
dc.contributor.authorChaná Cuevas, Pedro
dc.contributor.authorIbáñez, Agustín
dc.contributor.authorChaigneau, Sergio
dc.contributor.authorGarcía, Adolfo M
dc.coverage.spatialReino Unido
dc.date.accessioned2026-08-04T17:05:14Z
dc.date.available2026-08-04T17:05:14Z
dc.date.issued2024-01-09
dc.description.abstractCognitive studies on Parkinson’s disease (PD) reveal abnormal semantic processing. Most research, however, fails to indicate which conceptual properties are most affected and capture patients’ neurocognitive profiles. Here, we asked persons with PD, healthy controls, and individuals with behavioral variant frontotemporal dementia (bvFTD, as a disease control group) to read concepts (e.g., ‘sun’) and list their features (e.g., hot). Responses were analyzed in terms of ten word properties (including concreteness, imageability, and semantic variability), used for group-level comparisons, subject-level classification, and brain-behavior correlations. PD (but not bvFTD) patients produced more concrete and imageable words than controls, both patterns being associated with overall cognitive status. PD and bvFTD patients showed reduced semantic variability, an anomaly which predicted semantic inhibition outcomes. Word-property patterns robustly classified PD (but not bvFTD) patients and correlated with disease-specific hypoconnectivity along the sensorimotor and salience networks. Fine-grained semantic assessments, then, can reveal distinct neurocognitive signatures of PD.
dc.identifier.citationnpj Parkinson's Disease, Vol. 10, N°. 15 (2024)
dc.identifier.doihttps://doi.org/10.1038/s41531-024-00630-4
dc.identifier.issne2373-8057
dc.identifier.orcidhttps://orcid.org/0000-0002-6228-2678
dc.identifier.urihttps://hdl.handle.net/20.500.12254/7688
dc.language.isoen
dc.publisherNature Portfolio
dc.subjectParkinson's disease
dc.subjectSemantic memory
dc.subjectNeurocognitive profiles
dc.subjectConcreteness
dc.subjectImageability
dc.subjectSemantic variability
dc.subjectFrontotemporal dementia
dc.titleNeurocognitive correlates of semantic memory navigation in Parkinson’s disease
dc.typeArticle
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