Antimicrobial effect of copper nanoparticles on relevant supragingival oral bacteria

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dc.contributor.authorOetiker, Nia
dc.contributor.authorSalinas, Daniela
dc.contributor.authorLucero-Mora, Joaquín
dc.contributor.authorOrellana, Rocío
dc.contributor.authorQuiroz-Muñoz, Mariana
dc.contributor.authorBravo, Denisse
dc.contributor.authorPérez-Donoso, José M.
dc.date.accessioned2024-03-27T16:12:04Z
dc.date.available2024-03-27T16:12:04Z
dc.date.issued2024-03-20
dc.description.abstractCopper nanoparticles (Cu NPs) show promise in dentistry for combating bacterial dysbiosis and tooth decay. Understanding their effects on commensal versus pathogenic bacteria is vital for maintaining oral health balance. While Cu NPs demonstrate antibacterial properties against various oral bacteria, including common pathogens associated with tooth decay, their impact on commensal bacteria requires careful examination. In our work, we analyzed three types of Cu NPs for their effects on the growth, viability, and biofilm formation of representative caries-associated and commensal oral bacteria. S. sanguinis showed high tolerance to all Cu NPs, while L. rhamnosus was highly sensitive. Oxide-Cu NPs exhibited a stronger inhibitory effect on pathobionts compared with commensal bacteria. Moreover, the biofilm formation of the key cariogenic bacteria S. mutans was reduced, with minimal negative effects on commensal species’ biofilm formation. All our results showed that CuO nanoparticles (CuO NPs) exhibit reduced toxicity toward commensal bacteria growth and development but have a strong impact on pathogens. This suggests their potential for targeted treatments against pathogenic bacteria, which could help in maintaining the balance of the oral bacterial community.
dc.description.sponsorshipThis research was supported by the Agencia Nacional de Investigación y Desarrollo (ANID) Grant No. 3190555; Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) Grant No. 1200870; and Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) Grant No. 1200877.
dc.identifier.citationMicroorganisms, Vol 12, N° 3, 624, (2024) p. 1-15.
dc.identifier.doihttps://doi.org/10.3390/microorganisms12030624
dc.identifier.issn2076-2607
dc.identifier.orcid0000-0002-1046-6045
dc.identifier.urihttp://hdl.handle.net/20.500.12254/3651
dc.language.isoen
dc.publisherMDPI
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectCaries
dc.subjectBiofilm
dc.subjectCopper
dc.subjectNanoparticles
dc.subjectStreptococcus
dc.subjectLactobacillus
dc.titleAntimicrobial effect of copper nanoparticles on relevant supragingival oral bacteria
dc.typeArticle
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