Effectiveness of Vitamin D Supplementation on Biochemical, Clinical, and Inflammatory Parameters in Patients with Different Types of Diabetes: A Systematic Review and Meta-Analysis

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dc.contributor.authorBruna-Mejías, Alejandro
dc.contributor.authorValdivia-Arroyo, Rocío
dc.contributor.authorBecerra-Rodríguez, Emelyn Sofía
dc.contributor.authorClasing-Cárdenas, Ignacio
dc.contributor.authorCastaño-Gallego, Yesica Tatiana
dc.contributor.authorGranite, Guinevere
dc.contributor.authorOrellana-Donoso, Mathias
dc.contributor.authorOyanedel-Amaro, Gustavo
dc.contributor.authorNova-Baeza, Pablo
dc.contributor.authorCifuentes-Suazo, Gloria
dc.contributor.authorSuazo Santibañez, Alejandra
dc.contributor.authorSanchis-Gimeno, Juan
dc.contributor.authorGutiérrez Espinoza, Héctor
dc.contributor.authorValenzuela Fuenzalida, Juan José
dc.date.accessioned2025-09-30T14:17:01Z
dc.date.available2025-09-30T14:17:01Z
dc.date.issued2025-09-18
dc.description.abstractBackground and Aims: Numerous clinical and observational studies have examined the role of vitamin D in glycemic control and metabolic regulation among diabetic patients, but findings remain inconsistent. This meta-analysis aimed to assess the effects of vitamin D supplementation on glycosylated hemoglobin (HbA1c%), HOMA-IR, HOMA-β, LDL cholesterol, total cholesterol, triglycerides, fasting insulin, fasting plasma glucose, C-reactive protein, and the likelihood of reversion to normoglycemia in prediabetic individuals. Methods: A comprehensive search of multiple databases was performed using keywords including “diabetes mellitus,” “type 2 diabetes,” “vitamin D supplementation,” and “VD supplementation.” Twenty studies met the inclusion criteria. Results: Vitamin D supplementation was associated with significant improvements across several parameters, including HOMA-β (SMD = 0.71; 95% CI: 0.63–0.80; p < 0.00001), HDL cholesterol (SMD = 0.07; 95% CI: 0.05–0.09; p < 0.00001), and others (SMD = −0.40; 95% CI: −0.45 to −0.34; p < 0.00001). Conclusions: Vitamin D supplementation appears to provide beneficial effects on glycemic, lipid, and inflammatory markers in patients with diabetes and prediabetes. Specifically, supplementation significantly reduced HbA1c%, HOMA-IR, LDL cholesterol, total cholesterol, triglycerides, fasting insulin, fasting glucose, and C-reactive protein while increasing the rate of normoglycemia among prediabetic individuals. Further research is needed to strengthen the evidence base regarding vitamin D’s role in diabetes management.
dc.identifier.citationNutrients, Vol. 17, N°18, 2991 (2025) p. 1-38.
dc.identifier.doihttps://doi.org/10.3390/nu17182991
dc.identifier.issn2072-6643
dc.identifier.orcidhttps://orcid.org/0000-0002-1781-062X
dc.identifier.urihttps://hdl.handle.net/20.500.12254/4328
dc.language.isoen
dc.publisherMDPI
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectVitamin D supplementation
dc.subjectVitamin D
dc.subjectDiabetes mellitus type 1
dc.subjectDiabetes type 2
dc.titleEffectiveness of Vitamin D Supplementation on Biochemical, Clinical, and Inflammatory Parameters in Patients with Different Types of Diabetes: A Systematic Review and Meta-Analysis
dc.typeArticle
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