The Effect of Diabetes Mellitus on Central Corneal Thickness Values: A Systematic Review and Meta-Analysis

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dc.contributor.authorUzunoglu, Arda
dc.contributor.authorValenzuela Fuenzalida, Juan José
dc.contributor.authorMorales-Calderón, Karin
dc.contributor.authorAguilar-Aguirre, Isidora
dc.contributor.authorBruna-Mejías, Alejandro
dc.contributor.authorNova-Baeza, Pablo
dc.contributor.authorOrellana-Donoso, Mathias
dc.contributor.authorOyanedel-Amaro, Gustavo
dc.contributor.authorSuazo Santibañez, Alejandra
dc.contributor.authorSanchis-Gimeno, Juan A.
dc.contributor.authorLeón Rojas, Jose E.
dc.contributor.authorGranite, Guinevere
dc.date.accessioned2025-09-30T14:46:19Z
dc.date.available2025-09-30T14:46:19Z
dc.date.issued2025-09-06
dc.description.abstractDiabetes mellitus (DM) is a chronic metabolic disorder that can induce systemic and ocular complications. Among the latter, an increase in central corneal thickness (CCT) has been reported, potentially affecting endothelial function and increasing the risk of ocular disease. This study aimed to determine the impact of DM on CCT and to assess its correlation with diabetes duration and glycosylated hemoglobin (HbA1c) levels. A systematic literature search was conducted in Web of Science (1980–2025) following a PICO-based strategy. Observational studies evaluating CCT in diabetic patients were included. Data were analyzed using a random-effects model. Statistical heterogeneity was assessed with χ2 test, p values, and I2 index. Publication bias was evaluated using Begg’s funnel plot and Egger’s regression test. Twenty-nine studies were included in the meta-analysis. Diabetic patients showed significantly higher CCT values compared to controls, particularly in those with long-standing DM (p < 0.001) and poor glycemic control (HbA1c, p < 0.001). Egger’s regression suggested an association between increasing CCT, disease duration, and HbA1c levels, while funnel plot asymmetry indicated potential publication bias. CCT appears to increase in patients with long-term DM and inadequate glycemic control. These findings highlight the relevance of CCT assessment as a potential indicator of corneal changes in diabetic patients.
dc.identifier.citationInternational Journal of Molecular Sciences, Vol. 26, N°17, 8695 (2025) p. 1-19.
dc.identifier.doihttps://doi.org/10.3390/ijms26178695
dc.identifier.issn1422-0067
dc.identifier.orcidhttps://orcid.org/0000-0002-1781-062X
dc.identifier.urihttps://hdl.handle.net/20.500.12254/4329
dc.language.isoen
dc.publisherMDPI
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectCentral corneal thickness
dc.subjectDiabetes mellitus
dc.subjectCorneal disease
dc.titleThe Effect of Diabetes Mellitus on Central Corneal Thickness Values: A Systematic Review and Meta-Analysis
dc.typeArticle
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