Therapeutic plasma exchange in critically ill children: experience of the pediatric intensive care unit of two centers in Chile

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dc.contributor.authorBustos B, Raul
dc.contributor.authorHickmann O, Lilian
dc.contributor.authorCruces R, Pablo
dc.contributor.authorDíaz, Franco
dc.date.accessioned2021-12-17T14:46:59Z
dc.date.available2021-12-17T14:46:59Z
dc.date.issued2021-06-04
dc.descriptionEl texto quedará disponible en el Repositorio Institucional luego de 12 meses de su publicación debido al embargo definido por la editorial
dc.description.abstractIntroduction : Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique used in a wide spectrum of diseases. We aim to review the indications, complications, and outcomes of critically ill children who received TPE and to compare a membrane versus centrifugal method in this cohort. Methods : A retrospective observational study in two pediatric intensive care units in Chile during eight years (2011–2019) Results: A total of 36 patients underwent 167 TPE sessions (20 centrifugation and 16 membrane- based). The more frequent indications for TPE were autoimmune neurological diseases in 14 cases, renal diseases (9), and rheumatological disorders (5). 58% of children received other immunomodulatory therapy. According to ASFA, 45% of cases were I-II category, 50% to III, and 5% not classified. Response to treatment was complete in 64% (23/36) and partial in 33% (12/36). Complications occurred in 17.4% of sessions, and the most frequent was transient hypotension during the procedure. Overall survival at discharge from the PICU was 92%. Patients who received TPE as a single therapy (n = 26) survived 96%. The clinical outcomes between the two apheresis methods were similar. Survivors had a significantly lower PELOD score on admission (14.5 vs. 6.5, p= 0.004). Conclusions: TPE is mainly indicated as a rescue treatment in neurological autoimmune diseases refractory to conventional immunomodulatory treatment. Complications in critically ill children are mild and low. The outcome in children requiring TPE as a single therapy is good, and no differences were observed with centrifugation or membrane method.es
dc.identifier.citationTransfus Apher Sci.2021;60(5):103181. DOI: 10.1016/j.transci.2021.103181es
dc.identifier.issn1473-0502
dc.identifier.orcid0000-0003-4763-074Xes
dc.identifier.orcidhttps://doi.org/10.1016/j.transci.2021.103181
dc.identifier.urihttp://hdl.handle.net/20.500.12254/2159
dc.language.isoen_USes
dc.publisherElsevieres
dc.relation.ispartofseriesTransfusion and Apheresis Science;
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subject.otherTherapeutic plasma exchangees
dc.subject.otherPlasmapheresises
dc.subject.otherAutoimmune encephalitises
dc.subject.otherPediatricses
dc.titleTherapeutic plasma exchange in critically ill children: experience of the pediatric intensive care unit of two centers in Chilees
dc.typeArtículoes
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