Examinando por Autor "Konschake, Marko"

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    A Systematic Review with a Meta-Analysis of the Morphological Variants of the Corpus Callosum: Related Neurocognitive Clinical Implications
    (Elsevier, 2025) Valenzuela Fuenzalida, Juan José; Orellana-Hidalgo, Sebastián; Baeza-Garrido, Vicente; Trujillo-Riveros, Martin; Aguilar-Aguirre, Isidora; Nova-Baeza, Pablo; Orellana-Donoso, Mathias; Cifuentes-Suazo, Gloria; Bruna Mejías, Alejandro; Casanova-Martinez, Daniel; Sanchis-Gimeno, Juan; Piagkou, Maria; Triantafyllou, George; Konschake, Marko
    Background: Corpus callosum agenesis (CCA) occurs in approximately 1 in every 4000 births and is identified in 3–5% of individuals evaluated through neuroimaging for neurodevelopmental disorders. The combined prevalence of CCA and hypoplasia is estimated to range from 1.8 to 10 in every 10,000 births. Methods: The online databases Medline, Scopus, Web of Science, Google Scholar, Cumulative Index to Nursing and Allied Health Literature, and Latin American and Caribbean Literature in Health Sciences were searched until May 2025. Two authors independently conducted the search, selected the studies, and extracted the data. The methodological quality of the studies was assessed using the Anatomical Quality Assessment tool. A random effects model was used to estimate the pooled prevalence. Results: A total of 46 studies met the established selection criteria. In this analysis, 15 articles were included in the meta-analysis, which involved a total of 5,118,037 subjects. The overall prevalence of CCA was 18% (confidence interval = 10%–25%). The subgroup analysis revealed a significant difference in the prevalence of CCA among the Asian continent compared to the other four continents (P-value 0.001). Conclusions: Early diagnosis of CCA during the fetal stage can enable specialists to implement more effective treatments and reduce the likelihood of neurofunctional impairments. Furthermore, understanding the morphological characteristics of CCA can assist in making an early and accurate diagnosis, minimizing the need for differential diagnoses that could interfere with the functioning of the interhemispheric connection system and brain functional connections.
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    Infraorbital canal variants and its clinical and surgical implications: A systematic review
    (Springer Nature, 2024-04-29) Orellana-Donoso, Mathias; Romero Zucchino, Diego; Fuentes Abarca, Alonso; Aravena Ríos, Priscila; Sanchis Gimeno, Juan; Konschake, Marko
    Background: Recent literature highlights anomalous cranial nerves in the sinonasal region, notably in the sphenoid and maxillary sinuses, linked to anatomical factors. However, data on the suspended infraorbital canal (IOC) variant is scarce in cross-sectional imaging. Anatomical variations in the sphenoid sinuses, including optic, maxillary, and vidian nerves, raise interest among specialists involved in advanced sinonasal procedures. The infraorbital nerve's (ION) course along the orbital floor and its abnormal positioning within the orbital and maxillary sinus region pose risks of iatrogenic complications. A comprehensive radiological assessment is crucial before sinonasal surgeries. Cone-beam computed tomography (CBCT) is preferred for its spatial resolution and reduced radiation exposure. Objective: The aim of this study was to describe the prevalence of anatomical variants of the infraorbital canal (IOC) and report its association with clinical condition or surgical implication. Methods: We searched Medline, Scopus, Web of Science, Google Scholar, CINAHL, and LILACS databases from their inception up to June 2023. Two authors independently performed the search, study selection, data extraction, and assessed the methodological quality with assurance tool for anatomical studies (AQUA). Finally, the pooled prevalence was estimated using a random effects model. Results: Preliminary results show that three types are prevalent, type 1: the IOC does not bulge into the maxillary sinus (MS); therefore, the infraorbital foramen through the anterior wall of MS could be used for identification of the ION. Type 2: the IOC divided the orbital floor into medial and lateral aspects. Type 3: the IOC hangs in the MS and the entire orbital floor lying above the IOC. From which the clinical implications where mainly surgical, in type 1 the infraorbital foramen through the anterior wall of MS could be used for identification of the ION, while in type 2, since the lateral orbital floor could not be directly accessed an inferiorly transposition of ION is helpful to expose the lateral orbital wall directly with a 0 scope; or using angled endoscopes and instruments, however, the authors opinion is that direct exposure potentially facilitates the visualization and management in complex situations such as residual or recurrent mass, foreign body, and fracture located at the lateral aspect of the canal. Lastly, in type 3, the ION it's easily exposed with a 0° scope. Conclusions: This systematic review identified four IOC variants: Type 1, within or below the MS roof; Type 2, partially protruding into the sinus; Type 3, fully protruding into the sinus or suspended from the roof; and Type 4, in the orbital floor. Clinical recommendations aim to prevent nerve injuries and enhance preoperative assessments. However, the lack of consistent statistical methods limits robust associations between IOC variants and clinical outcomes. Data heterogeneity and the absence of standardized reporting impede meta-analysis. Future research should prioritize detailed reporting, objective measurements, and statistical approaches for a comprehensive understanding of IOC variants and their clinical implications. Open Science Framework (OSF): https://doi.org/10.17605/OSF.IO/UGYFZ .
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    Ítem
    The Gastric Vein Variants: An Evidence-Based Systematic Review of Prevalence and Clinical Considerations
    (MDPI, 2025-05-22) Bruna-Mejías, Alejandro; Salgado-Torres, Cristian; Cáceres-Gálvez, Constanza; Rodriguez-Osorio, Benjamin; Orellana-Donoso, Mathias; Nova-Baeza, Pablo; Suazo Santibañez, Alejandra; Oyanedel-Amaro, Gustavo; Sanchis-Gimeno, Juan; Piagkou, Maria; Triantafyllou, George; Konschake, Marko; Valenzuela Fuenzalida, Juan José
    The objective of the present systematic study was to analyze and characterize the gastric vein (GV) variations to understand their significance within clinical contexts, particularly in gastric and liver surgeries and managing conditions associated with the portal vein system. Methods: We conducted a systematic review, examining various databases, including Medline, Scopus, Web of Science, Google Scholar, CINAHL, and EMBASE, up to April 2025. Two independent authors conducted the literature search, selected pertinent studies, and extracted relevant data. The methodological quality of the studies was evaluated utilizing the Assessment Tool for Anatomical Studies (AQUA). The pooled prevalence was estimated through the application of a random effects model. Results: Among the 279 articles reviewed, 11 studies were ultimately incorporated into the systematic analysis, encompassing 47,993 subjects. The pooled prevalence of GV variants was determined to be 8.32%, revealing considerable heterogeneity (I2 = 98.92%). A subgroup analysis showed a greater prevalence of GV variants in diagnostic imaging studies than in cadaveric studies, with a higher frequency observed in males than in females. Conclusions: The morphological variability of the GVs holds clinical significance, as it may significantly impact the management of abdominal disorders, particularly during surgical and endovascular interventions. This study emphasizes the necessity of thorough preoperative evaluations to identify these variations, thereby minimizing surgical complications and enhancing therapeutic outcomes for patients suffering from gastric and portal vein system disorders. Integrating advanced imaging techniques into clinical practice may facilitate improved surgical and therapeutic planning.