Association between adipose tissue characteristics and metabolic flexibility in humans: A systematic review
Date
2021-12-03
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Journal Title
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Publisher
Frontiers Media
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2296-861X
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Abstract
Adipose tissue total amount, distribution, and phenotype influence metabolic health.
This may be partially mediated by the metabolic effects that these adipose tissue
characteristics exert on the nearby and distant tissues. Thus, adipose tissue may
influence the capacity of cells, tissues, and the organism to adapt fuel oxidation to fuel
availability, i.e., their metabolic flexibility (MetF). Our aim was to systematically review
the evidence for an association between adipose tissue characteristics and MetF in
response to metabolic challenges in human adults. We searched in PubMed (last search
on September 4, 2021) for reports that measured adipose tissue characteristics (total
amount, distribution, and phenotype) and MetF in response to metabolic challenges (as
a change in respiratory quotient) in humans aged 18 to <65 years. Any study design
was considered, and the risk of bias was assessed with a checklist for randomized
and non-randomized studies. From 880 records identified, 22 remained for the analysis,
10 of them measured MetF in response to glucose plus insulin stimulation, nine in
response to dietary challenges, and four in response to other challenges. Our main
findings were that: (a) MetF to glucose plus insulin stimulation seems inversely associated
with adipose tissue total amount, waist circumference, and visceral adipose tissue; and
(b) MetF to dietary challenges does not seem associated with adipose tissue total amount
or distribution. In conclusion, evidence suggests that adipose tissue may directly or
indirectly influence MetF to glucose plus insulin stimulation, an effect probably explained
by skeletal muscle insulin sensitivity
Description
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This study was funded by ANID/CONICYT FONDECYT
Iniciación 11180361 to RF-V.
Citation
Glaves A, Díaz-Castro F, Farías J, Ramírez-Romero R, Galgani JE and Fernández-Verdejo R (2021) Association Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review. Front. Nutr. 8:744187. doi: 10.3389/fnut.2021.744187